bs-3428R [Primary Antibody]
Stat2 (Tyr690) Polyclonal Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: Stat2 Tyr690

Specificity: This phosphorylation site is homologous to that of Tyr689 in Mouse and Tyr690 in Rat.

Modification Site: Tyr690

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 6773

Swiss Prot: P52630

Source: KLH conjugated synthetic phosphopeptide derived from human Stat2 around the phosphorylation site of Tyr690

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Background:

Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
ELISA(1:500-1000)
IHC-P(1:200-400)
IHC-F(1:100-500)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)
ICC(1:100-500)

Predicted Molecular Weight: 94


Cross Reactive Species: Human
Mouse
Rat

Predicted Cross Reactive Species: Dog
Horse

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Medeiros et al. JAK3 as an Emerging Target for Topical Treatment of Inflammatory Skin Diseases. (2016) PLoS.On. 11:e0164080Read more>>
  • Collotta D et al. Baricitinib counteracts metaflammation, thus protecting against diet-induced metabolic abnormalities in mice. Mol Metab.2020 Sep;39:101009.Read more>>
  • Chen Y et al. Dendritic cells-derived interferon-1 ameliorated inflammatory bone destruction through inhibiting osteoclastogenesis. Cell Death Dis. 2020 Jun 2;11(6):414.Read more>>
  • Zhuo Han. et al. New insights into Vitamin C function: Vitamin C induces JAK2 activation through its receptor-like transporter SVCT2. Int J Biol Macromol. 2021 Mar;173:379Read more>>
  • Changjiang Liu. et al. Cypermethrin triggers YY1-mediated testosterone biosynthesis suppression. Ecotox Environ Safe. 2021 Dec;225:112792Read more>>
  • Wanze Zhang. et al. Novaferon gene modification promotes NK92 cell anti-tumor activity. INT IMMUNOPHARMACOL. 2023 Sep;122:110613Read more>>
  • Cheng Zhang. et al. Secreted PTEN binds PLXDC2 on macrophages to drive antitumor immunity and tumor suppression. DEV CELL. 2024 27Read more>>
VALIDATION IMAGES

Formalin-fixed and paraffin embedded rat brain labeled with Anti-Phospho-Stat2 (Tyr690) Polyclonal Antibody, Unconjugated (bs-3428R) at 1:200 followed by conjugation to the secondary antibody and DAB staining


Mouse brain lysates probed with Stat2 (Tyr690) Polyclonal Antibody, unconjugated (bs-3428R) at 1:300 overnight at 4°C followed by a conjugated secondary antibody for 60 minutes at 37°C.