bs-3010R-Cy5 [Conjugated Primary Antibody]
Bax (Ser184) Polyclonal Antibody, Cy5 Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: Bax Ser184

Modification Site: Ser184

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 581

Swiss Prot: Q07812

Source: KLH conjugated synthetic phosphopeptide derived from human Bax around the phosphorylation site of Ser184

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.

Conjugation: Cy5

Excitation/ Emission: 625,650nm/670nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
FCM(1:20-100)

Predicted Molecular Weight: 21


Cross Reactive Species: Human
Mouse
Rat

Predicted Cross Reactive Species: Dog
Cow
Sheep
Pig

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Park, Ga Bin, et al. "Melphalan-Induced Apoptosis of EBV-Transformed B Cells through Upregulation of TAp73 and XAF1 and Nuclear Import of XPA." The Journal of Immunology (2013): 1203442.Read more>>
  • Gao, Xiu-Fang, et al. "Urocortin-2 suppression of p38-MAPK signaling as an additional mechanism for ischemic cardioprotection." Molecular and Cellular Biochemistry: 1-12.Read more>>
  • Park, Gabin, et al. "Berberine induces mitochondrial apoptosis of EBV-transformed B cells through p53-mediated regulation of XAF1 and GADD45α." International Journal of Oncology.Read more>>
  • Daverey, Amita, and Sandeep K. Agrawal. "Curcumin alleviates oxidative stress and mitochondrial dysfunction in astrocytes." Neuroscience 333 (2016): 92-103.Read more>>
  • Kyung Hye Lee. et al. Role of ATP5G3 in sodium nitroprusside-induced cell death in cervical carcinoma cells. J BIOCHEM MOL TOXIC. 2022 Dec;:e23267Read more>>
VALIDATION IMAGES