bs-2962R-Cy3 [Conjugated Primary Antibody]
Syncytin 1 Polyclonal Antibody, Cy3 Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: Syncytin 1

Immunogen Range: 451-538/538


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 30816

Swiss Prot: Q9UQF0

Source: KLH conjugated synthetic peptide derived from human Syncytin 1

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. May induce fusion through binding of SLC1A4 and SLC1A5 (PubMed:10708449, PubMed:12050356, PubMed:23492904). Endogenous envelope proteins may have kept, lost or modified their original function during evolution. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein (SU) mediates receptor recognition, while the transmembrane protein (TM) acts as a class I viral fusion protein. The protein may have at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of membranes.

Conjugation: Cy3

Excitation/ Emission: 512,550nm/570,615nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)

Predicted Molecular Weight: 33/58


Cross Reactive Species: Human
Mouse

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Díaz-Carballo, David, et al. "Therapeutic potential of antiviral drugs targeting chemorefractory colorectal adenocarcinoma cells overexpressing endogenous retroviral elements." Journal of Experimental & Clinical Cancer Research 34.1 (2015): 81.Read more>>
  • Díaz-Carballo et al. Cytotoxic stress induces transfer of mitochondria-associated human endogenous retroviral RNA and proteins between cancer cells. (2017) Oncotarget. 8:95945-95964Read more>>
  • Li Zhuo-Hang. et al. The roles of ADAMDEC1 in trophoblast differentiation during normal pregnancy and preeclampsia. MOLECULAR HUMAN REPRODUCTION. 2022 MayRead more>>
  • Whitlock, Jarred M.. et al. Cell surface-bound La protein regulates the cell fusion stage of osteoclastogenesis. NAT COMMUN. 2023 Feb;14(1):1-19Read more>>
  • Wu Zhi-Hong. et al. miR-181d-5p, which is upregulated in fetal growth restriction placentas, inhibits trophoblast fusion via CREBRF. J ASSIST REPROD GEN. 2023 Aug;:1-13Read more>>
  • Jiao Wang. et al. Influenza A virus infection disrupts the function of syncytiotrophoblast cells and contributes to adverse pregnancy outcomes. J MED VIROL. 2024 May;96(6):e29687Read more>>
  • Lita Rakhma YUSTINASARI. et al. Appearance of small extracellular vesicles in the mouse pregnant serum and the localization in placentas. J VET MED SCI. 2024 15Read more>>
VALIDATION IMAGES