bs-2807R-Biotin

DATASHEET

Host: Rabbit

Target Protein: CD161

Immunogen Range: 151-225/225

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 3820

Swiss Prot: Q12918

Source: KLH conjugated synthetic peptide derived from human CD161/NK11

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C for 12 months.

Background:

Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.

Conjugation: Biotin

Excitation/ Emission: N/A

Size: 100ul

Concentration: 1ug/ul

Applications: ELISA(1:5000-10000)

Predicted Molecular Weight: 25

Cross Reactive Species: Human
Rat

For research use only. Not intended for diagnostic or therapeutic use.