DATASHEET
Host:
Rabbit
Target Protein:
NGR2
Immunogen Range:
241-337/337
Clonality:
Polyclonal
Isotype:
IgG
Entrez Gene:
3460
Swiss Prot:
P38484
Source:
KLH conjugated synthetic peptide derived from human IFNGR2
Purification:
Purified by Protein A.
Storage Buffer:
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage:
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Background:
Part of the receptor for interferon gamma. Required for signal transduction. This accessory factor is an integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2.
PRODUCT SPECIFIC PUBLICATIONS
- Kunis, Gilad, et al. "IFN-γ-dependent activation of the brain’s choroid plexus for CNS immune surveillance and repair." Brain (2013): awt259.Read more>>
- Xia, Xj, et al. "Autophagy mediated by arginine depletion activation of the nutrient sensor GCN2 contributes to interferon-γ-induced malignant transformation of primary bovine mammary epithelial cells." Cell Death Discovery 2 (2016).Read more>>
- Jing Miao. et al. Carnosine Synthase 1 Contributes to Interferon Gamma-Induced Arginine Depletion via Mitogen-activated Protein Kinase 11 Signaling in Bovine Mammary Epithelial Cells. J INTERF CYTOK RES. 2022 Jul 27Read more>>
VALIDATION IMAGES
Formalin-fixed and paraffin embedded human labeled with Anti-IFNGR2 Polyclonal Antibody, Unconjugated (bs-2710R) at 1:200 followed by conjugation to the secondary antibody and DAB staining
Lane 1: Human 293T cell lysates; Lane 2: Human K562 cell lysates; Lane 3: Human U937 cell lysates probed with IFNGR2 Polyclonal Antibody, Unconjugated (bs-2710R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.