bs-2698R-HRP [Conjugated Primary Antibody]
MCT4 Polyclonal Antibody, HRP Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: MCT4

Immunogen Range: 401-465/465


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 9123

Swiss Prot: O15427

Source: KLH conjugated synthetic peptide derived from human MCT4

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).

Conjugation: HRP

Excitation/ Emission: N/A

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
ELISA(1:500-1000)
IHC-P(1:200-400)
IHC-F(1:100-500)

Predicted Molecular Weight: 52


Cross Reactive Species: Human
Mouse
Rat

Predicted Cross Reactive Species: Dog
Cow
Horse
Chicken

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Prado-Garcia H et al. Lactic Acidosis in the Presence of Glucose Diminishes Warburg Effect in Lung Adenocarcinoma Cells. Front Oncol. 2020 Jun 12;10:807.Read more>>
  • Carolina Manosalva. et al. D-Lactate Increases Cytokine Production in Bovine Fibroblast-Like Synoviocytes via MCT1 Uptake and the MAPK, PI3K/Akt, and NFB Pathways. Animals-Basel. 2020 Nov;10(11):2105Read more>>
  • Qingxian Li. et al. Glucocorticoid caused lactic acid accumulation and damage in human chondrocytes via ROS-mediated inhibition of Monboxylate Transporter 4. Bone. 2021 Dec;:116299Read more>>
  • Xiao Han. et al. ZEB1 induces ROS generation through directly promoting MCT4 transcription to facilitate breast cancer. Exp Cell Res. 2022 Mar;412:113044Read more>>
  • Ruofan Yao. et al. Maternal obesity-associated disruption of polarized lactate transporter MCT4 expression in human placenta. REPROD TOXICOL. 2022 Sep;112:1Read more>>
  • P.P.M. Scariot. et al. Monocarboxylate transporters (MCTs) in skeletal muscle and hypothalamus of less or more physically active mice exposed to aerobic training. LIFE SCI. 2022 Oct;307:120872Read more>>
  • Pedro Paulo Menezes Scariot. et al. Living high - training low model applied to C57BL/6J mice: Effects on physiological parameters related to aerobic fitness and acid-base balance. LIFE SCI. 2023 Mar;317:121443Read more>>
  • Yunjia Zhang. et al. Macrophage MCT4 inhibition activates reparative genes and protects from atherosclerosis by histone H3 lysine 18 lactylation. CELL REP. 2024 May;43Read more>>
  • Carolin Kubelt. et al. Temporal and regional expression changes and co-staining patterns of metabolic and stemness-related markers during glioblastoma progression. EUR J NEUROSCI. 2024 MayRead more>>
VALIDATION IMAGES