bs-2654R [Primary Antibody]
LTB4-R1/BLTR Polyclonal Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: LTB4-R1/BLTR

Immunogen Range: 101-200/352


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 1241

Swiss Prot: Q15722

Source: KLH conjugated synthetic peptide derived from human LTB4-R1

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Background:

Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.

Size: 100ul

Concentration: 1ug/ul

Applications: ELISA(1:500-1000)
FCM(1:20-100)
IHC-P(1:200-400)
IHC-F(1:100-500)
IF(IHC-P)(1:50-200)

Predicted Molecular Weight: 39


Cross Reactive Species: Human
Mouse
Rat

Predicted Cross Reactive Species: Dog
Cow
Pig
Horse
Rabbit
Guinea Pig

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Wculek, S. Pre-metastatic neutrophils directly support highly tumourigenic breast cancer cells during lung metastasis via a leukotriene-ERK1/2 axis. Diss. UCL (University College London), 2016.Read more>>
  • Zinn, Sebastian, et al. "The leukotriene B4 receptors BLT1 and BLT2 form an antagonistic sensitizing system in peripheral sensory neurons." Journal of Biological Chemistry (2017): jbc-M116.Read more>>
  • Zhu et al. Resolvin E1 regulates osteoclast fusion via DC-STAMP and NFATc1. (2013) FASEB.J. 27:3344-53Read more>>
  • Malihe Eskandarpour. et al. Leukotriene B4 and Its Receptor in Experimental Autoimmune Uveitis and in Human Retinal Tissues: Clinical Severity and LTB4 Dependence of Retinal Th17 Cells. Am J Pathol. 2021 Feb;191:32Read more>>
  • Zhao, Xiu-Juan. et al. Therapeutic effect of the sulforaphane derivative JY4 on ulcerative colitis through the NF-B-p65 pathway. INFLAMMOPHARMACOLOGY. 2022 Aug;:1-12Read more>>
  • Alex Hopke. et al. Transcellular Biosynthesis of Leukotriene B4 Orchestrates Neutrophil Swarming to Fungi. ISCIENCE. 2022 Sep;:105226Read more>>
VALIDATION IMAGES

Formalin-fixed and paraffin-embedded liver of mouse embryo labeled with Anti-LTB4-R1/BLTR Polyclonal Antibody, Unconjugated(bs-2654R) 1:200, overnight at 4°C, The secondary antibody was Goat Anti-Rabbit IgG, Alexa Fluor 647 conjugated(bs-0295G-A647)used at 1:200 dilution for 40 minutes at 37°C.