Host: Rabbit
Target Protein: phospho-LRP5 (Thr1492)
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 4041
Swiss Prot: O75197
Source: KLH conjugated Synthesised phosphopeptide derived from human LRP5 around the phosphorylation site of Thr1492
Purification: Purified by Protein A.
Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Background:
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation.
Conjugation: HRP
Excitation/ Emission: N/A
Size: 100ul
Concentration: 1mg/ml
Applications:
ELISA(1:5000-10000)
IHC-P(1:100-500)
Predicted Molecular Weight: 176
Cross Reactive Species: Human
Predicted Cross Reactive Species:
Mouse
Rat
Dog
Cow
Pig
For research use only. Not intended for diagnostic or therapeutic use.