bs-2508R
[Primary Antibody]
CD11b/c Polyclonal Antibody
DATASHEET
Host: Rabbit
Target Protein: CD11b/c
Immunogen Range: 520-570/1163
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 3687
Swiss Prot: P20702
Source: KLH conjugated synthetic peptide derived from human CD11c
Purification: Purified by Protein A.
Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage: Store at -20°C for 12 months.
Background:
Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.
Size: 100ul
Concentration: 1ug/ul
Applications: FCM(1:20-100)
Predicted Molecular Weight: 128
Cross Reactive Species:
Human
Rat
For research use only. Not intended for diagnostic or therapeutic use.
PRODUCT SPECIFIC PUBLICATIONS
- Zhang, Xinwen, et al. "Peripheral Role of Cathepsin S in Th1 Cell-Dependent Transition of Nerve Injury-Induced Acute Pain to a Chronic Pain State." The Journal of Neuroscience 34.8 (2014): 3013-3022.Read more>>
- Di Filippo, C., et al. "Involvement of Proteasome and Macrophages M2 in the Protection Afforded by Telmisartan against the Acute Myocardial Infarction in Zucker Diabetic Fatty Rats with Metabolic Syndrome." Mediators of Inflammation 2014 (2014).Read more>>
- Ju, Huanyu, et al. "An effective cytokine adjuvant vaccine induces autologous T-cell response against colon cancer in an animal model." BMC immunology 17.1 (2016): 31.Read more>>
- Ahn, Jeonghyun, Phillip Ruiz, and Glen N. Barber. "Intrinsic self-DNA triggers inflammatory disease dependent on STING." The Journal of Immunology 193.9 (2014): 4634-4642.Read more>>
- Zhang et al. Proteus mirabilis inhibits cancer growth and pulmonary metastasis in a mouse breast cancer model. (2017) PLoS.On. 12:e0188960Read more>>
- Rossi et al. Activation of Melanocortin Receptors MC 1 and MC 5 Attenuates Retinal Damage in Experimental Diabetic Retinopathy. (2016) Mediators.Inflam. 2016:7368389Read more>>
- Ahn et al. Inflammation-driven carcinogenesis is mediated through STING. (2014) Nat.Commu. 5:5166Read more>>
- Liao et al. Bone mesenchymal stem cells co-expressing VEGF and BMP-6 genes to combat avascular necrosis of the femoral head. (2018) Exp.Ther.Med. 15:954-962Read more>>
- Ju et al. An effective cytokine adjuvant vaccine induces autologous T-cell response against colon cancer in an animal model. (2016) BMC.Immunol. 17:31Read more>>
- Wei C et al. Nanocolloids in drinking water increase the risk of obesity in mice by modulating gut microbesEnviron Int.2021 Jan;146:106302.Read more>>
- Hao X et al. Establishing a Multicolor Flow Cytometry to Characterize Cellular Immune Response in Chickens Following H7N9 Avian Influenza Virus InfectionViruses.2020 Dec 6;12(12):1396.Read more>>
- Zhao B et al. A TCM Formula YYWY Inhibits Tumor Growth in Non-Small Cell Lung Cancer and Enhances Immune-Response Through Facilitating the Maturation of Dendritic Cells. Front Pharmacol. 2020 Jun 9;11:798.Read more>>
- Xianmei Liu. et al. Tropomodulin1 Expression Increases Upon Maturation in Dendritic Cells and Promotes Their Maturation and Immune Functions. Front Immunol. 2020; 11: 587441Read more>>
- Yiyao Zhang. et al. Preparation of exosomes encapsulated nanohydrogel for accelerating wound healing of diabetic rats by promoting angiogenesis. Mat Sci Eng C-Mater. 2021 Jan;120:111671Read more>>
- Jinbo Li. et al. Low dose shikonin and anthracyclines coloaded liposomes induce robust immunogenetic cell death for synergistic chemo-immunotherapy. J Control Release. 2021 Jul;335:306Read more>>
- Jie Yu. et al. Synergistic enhancement of immunological responses triggered by hyperthermia sensitive Pt NPs via NIR laser to inhibit cancer relapse and metastasis. Bioact Mater. 2021 MayRead more>>
- Jie Yu. et al. Combining PD-L1 Inhibitors with Immunogenic Cell Death Triggered by Chemo-Photothermal therapy via a Thermosensitive Liposome System to Stimulate Tumor-specific Immunological Response. Nanoscale. 2021 JulRead more>>
- Wan, Guoyun. et al. Gene augmented nuclear-targeting sonodynamic therapy via Nrf2 pathway-based redox balance adjustment boosts peptide-based anti-PD-L1 therapy on colorectal cancer. J Nanobiotechnol. 2021 Dec;19(1):1-26Read more>>
- Jinbo Li. et al. Autophagy inhibition recovers deficient ICD-based cancer immunotherapy. BIOMATERIALS. 2022 Aug;287:121651Read more>>
- He, Xiaojing. et al. Inhibition of PD-1 Alters the SHP1/2-PI3K/Akt Axis to Decrease M1 Polarization of Alveolar Macrophages in Lung IschemiaCReperfusion Injury. INFLAMMATION. 2022 Nov;:1-16Read more>>
- Fenghe Du. et al. Imbalance of helper T cell subtypes and adipokine secretion in perivascular adipose tissue as a trigger of atherosclerosis in chronic Porphyromonas gingivalis W83 infection. MICROBES INFECT. 2023 Jul;:105181Read more>>
- Chen Hao. et al. Arula-7 powder improves diarrhea and intestinal epithelial tight junction function associated with its regulation of intestinal flora in calves infected with pathogenic Escherichia coli O1. MICROBIOME. 2023 Dec;11(1):1-14Read more>>
- Cheng Wenchao. et al. The Impact of Dipyridamole on Disease-Associated Microglia Phenotypic Transformation in White Matter Lesions Induced by Chronic Cerebral Hypoperfusion. NEUROCHEM RES. 2023 Dec;:1-14Read more>>
VALIDATION IMAGES
Human U937 cel\tCD11b/c Polyclonal Antibody, Unconjugated (bs-2508R) at 1:100 for 30 minutes followed by incubation with a PE Conjugated secondary (green) for 30 minutes compared to unstained control cells (blue), secondary only (light blue) and isotype control (orange).
Raw264.7 cells were incubated in 5% BSA blocking buffer for 30 min at room temperature. Cells were then stained with CD11c Polyclonal Antibody(bs-2508R)at 1:100 dilution in blocking buffer and incubated for 30 min at room temperature, washed twice with 2%BSA in PBS, followed by secondary antibody incubation for 40 min at room temperature. Acquisitions of 20,000 events were performed. Cells stained with primary antibody (green), and isotype control (orange).