DATASHEET
Host:
Rabbit
Target Protein:
CCL19/MIP-3 beta
Immunogen Range:
26-108/108
Clonality:
Polyclonal
Isotype:
IgG
Entrez Gene:
24047
Swiss Prot:
O70460
Source:
KLH conjugated synthetic peptide derived from mouse CCL19
Purification:
Purified by Protein A.
Storage Buffer:
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage:
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Background:
Strongly chemotactic for naive (L-selectinhi) CD4 T-cells and for CD8 T-cells and weakly attractive for resting B-cells and memory (L-selectinlo) CD4 T-cells. May play a role in promoting encounters between recirculating T-cells and dendritic cells and in the migration of activated B-cells into the T-zone of secondary lymphoid tissues. Binds to chemokine receptor CCR7. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
PRODUCT SPECIFIC PUBLICATIONS
- Borrelli, G. M., et al. "Immunohistochemical Investigation of Metastasis-Related Chemokines in Deep-Infiltrating Endometriosis and Compromised Pelvic Sentinel Lymph Nodes." Reproductive Sciences (2015): 1933719115592711.Read more>>
- Borrelli, Giuliano. Investigation of invasion factors in deep-infiltrating endometriosis. Diss. Freie Universität Berlin, 2015.Read more>>
- Xinli Niu. et al. Naringenin attenuates experimental autoimmune encephalomyelitis by protecting the intact of blood-brain barrier and controlling inflammatory cell migration. J Nutr Biochem. 2021 Mar;89:10856Read more>>
VALIDATION IMAGES
Formalin-fixed and paraffin embedded human endometrial cancer labeled with Anti-CCL19/MIP-3 beta Polyclonal Antibody, Unconjugated (bs-2454R) followed by conjugation to the secondary antibody
Lane 1: rat kidney lysates Lane 2: rat brain lysates probed with Anti CCL19/MIP-3 beta Polyclonal Antibody, Unconjugated (bs-2454R) at 1:200 in 4˚C. Followed by conjugation to secondary antibody (bs-0295G-HRP) at 1:3000 90min in RT. Predicted band 11kD. Observed band size: 11kD.