DATASHEET
Host:
Rabbit
Target Protein:
TGF beta Receptor I
Immunogen Range:
21-120/503
Clonality:
Polyclonal
Isotype:
IgG
Entrez Gene:
7046
Swiss Prot:
P36897
Source:
KLH conjugated synthetic peptide derived from human TGF beta Receptor I
Purification:
Purified by Protein A.
Storage Buffer:
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage:
Store at -20°C for 12 months.
Background:
The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
PRODUCT SPECIFIC PUBLICATIONS
- Longfei Xiao. et al. Dihydrotestosterone through blockade of TGF-/Smad signaling mediates the anti-fibrosis effect under hypoxia in canine Sertoli cells. J Steroid Biochem. 2022 Feb;216:106041Read more>>
- Zihui Wang. et al. Heat stress and hypoxia inhibit the secretion of androgens and induce epithelial-to-mesenchymal transition associated with activated TGF-_/Smad signaling in canine cryptorchidism. REPROD DOMEST ANIM. 2022 Jun 09Read more>>
VALIDATION IMAGES
Lane 1: Human Hela cell lysates; Lane 2: Human A549 cell lysates; Lane 3: Rat Testis tissue lysates probed with TGF beta Receptor I Polyclonal Antibody, Unconjugated (bs-23446R) at 1:1000 dilution and 4˚C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.
Lane 1: Mouse Placenta tissue lysates; Lane 2: Mouse Blood cell lysates; Lane 3: Mouse Lung tissue lysates; Lane 4: Mouse Stomach tissue lysates ; Lane 5: Rat Placenta tissue lysates ; Lane 6: Rat Blood cell lysates; Lane 7: Human Hela cell lysates; Lane 8: Human HepG2 cell lysates; Lane 9: Human Raji cell lysates probed with TGF beta Receptor I Polyclonal Antibody, Unconjugated (bs-23446R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.