bs-20788R [Primary Antibody]
CCR4 Polyclonal Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: CCR4

Immunogen Range: 171-220/360


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 1233

Swiss Prot: P51679

Source: KLH conjugated synthetic peptide derived from human CCR4

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Background:

High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
ELISA(1:500-1000)
IHC-P(1:200-400)
IHC-F(1:100-500)
IF()

Predicted Molecular Weight: 40


Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Qian-rong Wang. et al. CCL17 drives fibroblast activation in the progression of pulmonary fibrosis by enhancing the TGF-/Smad signaling. BIOCHEM PHARMACOL. 2023 Apr;210:115475Read more>>
VALIDATION IMAGES

Lane 1: Mouse Bone tissue lysates; Lane 2: Rat Bone tissue lysates probed with CCR4 Polyclonal Antibody, Unconjugated (bs-20788R) at 1:1000 dilution and 4˚C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.