bs-20449R-HRP [Conjugated Primary Antibody]
IL-1 Beta Polyclonal Antibody, HRP Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: IL-1 Beta

Immunogen Range: 181-269/269


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 3553

Swiss Prot: P01584

Source: KLH conjugated synthetic peptide derived from human IL-1 Beta

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

Conjugation: HRP

Excitation/ Emission: N/A

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
ELISA(1:500-1000)
IHC-P(1:200-400)

Predicted Molecular Weight: 17/32


Cross Reactive Species: Mouse

Predicted Cross Reactive Species: Human
Rat
Bee

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • "Chen X et al. A photothermal-triggered nitric oxide nanogenerator combined with siRNA for precise therapy of osteoarthritis by suppressing macrophage inflammation.Nanoscale. 2019 Apr 4;11(14):6693-6709."Read more>>
  • Wu Z et al. Pyroptosis engagement and bladder urothelial cells derived exosomes recruit mast cells and induce barrier dysfunction of bladder urothelium after UPEC infection. Am J Physiol Cell Physiol. 2019 Jun 26.Read more>>
  • Chujie Qu. et al. Nuclear receptor TLX may be through regulating the SIRT1/NF-B pathway to ameliorate cognitive impairment in chronic cerebral hypoperfusion. Brain Res Bull. 2021 Jan;166:142Read more>>
  • Jian Zhou. et al. A rapid juvenile murine model of nonalcoholic steatohepatitis (NASH): Chronic intermittent hypoxia exacerbates Western diet-induced NASH. Life Sci. 2021 Jul;276:119403Read more>>
  • Mingying Han. et al. Verapamil inhibits early acute liver failure through suppressing the NLRP3 inflammasome pathway. 2021 May 24Read more>>
  • Xiaoliang Hua. et al. CXCR3 antagonist AMG487 ameliorates experimental autoimmune prostatitis by diminishing Th1 cell differentiation and inhibiting macrophage M1 phenotypic activation. PROSTATE. 2022 Jun 14Read more>>
  • Yizhen Lyu. et al. Alterations of IL-1beta and TNF-alpha expression in RAW264.7 cell damage induced by two samples of PM2.5 with different compositions:. SCI PROGRESS-UK. 2022;105(3)Read more>>
  • Hui He. et al. Patchouli alcohol ameliorates depression-like behaviors through inhibiting NLRP3-mediated neuroinflammation in male stress-exposed mice. J AFFECT DISORDERS. 2023 JaRead more>>
  • Zhou Junjie. et al. Activation of autophagy inhibits the activation of NLRP3 inflammasome and alleviates sevoflurane-induced cognitive dysfunction in elderly rats. BMC NEUROSCI. 2023 Dec;24(1):1-14Read more>>
  • Han Junhui. et al. The Role of Endophilin A1 in Lipopolysaccharide-Induced Parkinsons Disease Model Mice. J PARKINSON DIS. 2023 Jun;Preprint(Preprint):1-14Read more>>
  • Wenliang Zha. et al. Mitochonic acid 5 rescues cardiomyocytes from doxorubicin-induced toxicity via repressing the TNF-/NF-B/NLRP3-mediated pyroptosis. INT IMMUNOPHARMACOL. 2023 Oct;123:110736Read more>>
  • Huang Lanyi. et al. Scorpion venom heat-resistant peptide alleviates mitochondrial dynamics imbalance induced by PM2.5 exposure by downregulating the PGC-1/SIRT3 signaling pathway. TOXICOL RES-UK. 2023 AugRead more>>
  • Hongjie Yang. et al. Low-intensity pulsed ultrasound treatment mitigates ventricular arrhythmias via inhibiting microglia-mediated neuroinflammation in heart failure rat model. INT IMMUNOPHARMACOL. 2024 Jan;126:111317Read more>>
  • Wuping Tan. et al. Celastrol exerts antiarrhythmic effects in chronic heart failure via NLRP3/Caspase-1/IL-1 signaling pathway. BIOMED PHARMACOTHER. 2024 Aug;177:117121Read more>>
VALIDATION IMAGES