bs-20205R

DATASHEET

Host: Rabbit

Target Protein: CDK9

Modification Site: Thr29

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 1025

Swiss Prot: P50750

Source: KLH conjugated Synthesised phosphopeptide derived from human CDK9 around the phosphorylation site of Thr29

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

Background:

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p-TEFb. The kinase complex containing this cyclin and the elongation factor can interact with, and act as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and was shown to be both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner were also found to be involved in the phosphorylation and regulation of the carboxy-terminal domain (CTD) of the largest RNA polymerase II subunit.

Size: 100ul

Concentration: 1ug/ul

Applications: IHC(1:100-500)

Predicted Molecular Weight: 43

Cross Reactive Species: Human
Mouse
Rat

Predicted Cross Reactive Species: Dog
Cow
Pig
Chicken
Zebrafish

For research use only. Not intended for diagnostic or therapeutic use.