bs-2016R-BF350 [Conjugated Primary Antibody]
Integrin Alpha V + Beta1 Antibody, AbBy Fluor® 350 Conjugated
www.biossusa.com
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DATASHEET

Host: Rabbit

Target Protein: Integrin Alpha V + Beta 1

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 3685, 3688

Source: Mixed KLH conjugated syntheticpeptides for human Integrin Alpha V and human Integrin Beta1

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro).

Conjugation: AbBy Fluor® 350

Excitation/ Emission: 346nm/442nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
FCM(1:20-100)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 114


Cross Reactive Species: Human
Mouse
Rat

Predicted Cross Reactive Species: Dog
Cow
Sheep
Pig
Horse

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Hendesi H, Barbe MF, Safadi FF, Monroy MA, Popoff SN (2015) Integrin Mediated Adhesion of Osteoblasts to Connective Tissue Growth Factor (CTGF/CCN2) Induces Cytoskeleton Reorganization and Cell Differentiation. PLoS ONE 10(2): e0115325. Read more>>
  • SHIRAKO H et al. Comparison of Anti-Inflammatory Analgesics for Mechanical Stress-induced Inflammation in a Human Synovial Sarcoma Cell Line. The Showa University Journal of Medical Sciences,2019 31(1), 51–62.  Read more>>
  • Wong L et al. Substrate Stiffness Directs Diverging Vascular Fates. Acta Biomater. 2019 Jul 19. pii: S1742-7061(19)30519-7.Read more>>
  • Liu S et al. Structural characterization of a novel polysaccharide from Panax notoginseng residue and its immunomodulatory activity on bone marrow dendritic cells. Int J Biol Macromol. 2020 Oct 15;161:797-809.Read more>>
  • Tingting Guo. et al. Lepidium meyenii Walpers polysaccharide and its cationic derivative re-educate tumor-associated macrophages for synergistic tumor immunotherapy. Carbohyd Polym. 2020 Dec;250:116904Read more>>
  • Harper, Amy K.. et al. Binding of Intracellular Myeloperoxidase to _V/_1 Integrin Serves as a Mechanism of Survival in Epithelial Ovarian Cancer. REPROD SCI. 2022 Jul;:1-1Read more>>
VALIDATION IMAGES