DATASHEET
Host:
Rabbit
Target Protein:
NTCP/SLC10A1
Immunogen Range:
21-120/349
Clonality:
Polyclonal
Isotype:
IgG
Entrez Gene:
6554
Swiss Prot:
Q14973
Source:
KLH conjugated synthetic peptide derived from human NTCP
Purification:
Purified by Protein A.
Storage Buffer:
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage:
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Background:
The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.
PRODUCT SPECIFIC PUBLICATIONS
- Yan Jiao. et al. Hepatocyte-derived exosome may be as a biomarker of liver regeneration and prognostic valuation in patients with acute-on-chronic liver failure. 2021 Jul 07Read more>>
- Tan Qin. et al. Oligomerization of the HBV/HDV functional receptor NTCP expressed in Sf9 insect cell. BBA-GEN SUBJECTS. 2022 Aug;:130224Read more>>
- Shu-Yan Gao. et al. iTRAQ Quantitative Proteomic Analysis of Different Expressed Proteins and Signal Pathways in Bakuchiol-Induced Hepatotoxicity. EVID-BASED COMPL ALT. 2022 Sep 19;2022:292824Read more>>
- Jing Zhao. et al. The choleretic role of tauroursodeoxycholic?acid exacerbates alpha-naphthylisothiocyanate?induced cholestatic liver injury through the FXR/BSEP pathway. J APPL TOXICOL. 2023 FebRead more>>
- Song Guochao. et al. Potential therapeutic action of tauroursodeoxycholic acid against cholestatic liver injury via hepatic Fxr/Nrf2 and CHOP-DR5-caspase-8 pathway. CLIN SCI. 2023 Apr;137(7):561-577Read more>>
- Lastuvkova Hana. et al. Carvedilol impairs bile acid homeostasis in mice: implication for nonalcoholic steatohepatitis. TOXICOL SCI. 2023 AugRead more>>
VALIDATION IMAGES
Human HepG2 and A431 lysates probed with Rabbit Anti-SLC10A1 Polyclonal Antibody, Unconjugated (bs-1958R) at 1:300 overnight at 4˚C. Followed by a conjugated secondary antibody (bs-0295G-HRP) at 1:5000 for 90 min at 37˚C.
Mouse liver lysates probed with Rabbit Anti-SLC10A1 Polyclonal Antibody, Unconjugated (bs-1958R) at 1:300 overnight at 4˚C. Followed by a conjugated secondary antibody (bs-0295G-HRP) at 1:5000 for 90 min at 37˚C.
Lane 1: Human HL60 cell lysates; Lane 2: Human K562 cell lysates; Lane 3: Human U-2 OS cell lysates probed with SLC10A1 Polyclonal Antibody, Unconjugated (bs-1958R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.