bs-19301R-APC

DATASHEET

Host: Rabbit

Target Protein: nNOS Ser1417

Modification Site: Ser1417

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 842

Swiss Prot: P55211

Source: KLH conjugated Synthesised phosphopeptide derived from human nNOS around the phosphorylation site of Ser1417

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.

Conjugation: APC

Excitation/ Emission: 650nm/660nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 160

Cross Reactive Species: Human
Rat
Xenopus laevis

Predicted Cross Reactive Species: Mouse
Zebrafish

For research use only. Not intended for diagnostic or therapeutic use.