bs-1893R-Cy7 [Conjugated Primary Antibody]
SLC6A4/5-HTT Polyclonal Antibody, Cy7 Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: SLC6A4/5-HTT

Immunogen Range: 401-500/630


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 6532

Swiss Prot: P31645

Source: KLH conjugated synthetic peptide derived from human 5-HTT

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.

Conjugation: Cy7

Excitation/ Emission: 743nm/767nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
IF(IHC-P)(1:50-200)

Predicted Molecular Weight: 70


Cross Reactive Species: Human
Mouse
Rat
Chicken

Predicted Cross Reactive Species: Dog
Cow
Sheep
Pig
Guinea Pig

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Dong, Xian-Zhe, et al. "A representative prescription for emotional disease, Ding-Zhi-Xiao-Wan restores 5-HT system deficit through interfering the synthesis and transshipment in chronic mild stress-induced depressive Rats." Journal of Ethnopharmacology (2013).Read more>>
  • Yu, Feng-Yan, et al. "Comparison of 5-hydroxytryptophan signaling pathway characteristics in diarrhea-predominant irritable bowel syndrome and ulcerative colitis." World Journal of Gastroenterology 22.12 (2016): 3451-3459.Read more>>
  • Wojtal, Kacper Andrzej, et al. "Down-regulation of duodenal SLC transporters and activation of pro-inflammatory signaling constitute the early response to high altitude in humans." American Journal of Physiology-Gastrointestinal and Liver Physiology (2014): ajpgi-00353.Read more>>
  • Bai, Yang, et al. "4-Chloro-DL-phenylalanine protects against monocrotaline‑induced pulmonary vascular remodeling and lung inflammation." International journal of molecular medicine 33.2 (2014): 373-382.Read more>>
  • Wang, Yun, et al. "Fluoxetine protects against methamphetamine‑induced lung inflammation by suppressing oxidative stress through the SERT/p38 MAPK/Nrf2 pathway in rats." Molecular Medicine Reports 15.2 (2017): 673-680.Read more>>
  • Huang X et al. The development of the serotonergic and dopaminergic systems during chicken mid-late embryogenesis. Mol Cell Endocrinol. 2019 Aug 1;493:110472.Read more>>
  • Lei Wu. et al. Ethanol Extract of Mao Jian Green Tea Attenuates Gastrointestinal Symptoms in a Rat Model of Irritable Bowel Syndrome with Constipation via the 5-hydroxytryptamine Signaling Pathway. FOODS. 2023 Jan;12(5):1101Read more>>
  • Paul C. Omaliko. et al. Impact of Dietary Fat Types on expression levels of Dopamine and Serotonin transporters in the Ileum of broiler chickens. POULTRY SCI. 2024 Jul;:104114Read more>>
VALIDATION IMAGES