DATASHEET
Host:
Rabbit
Target Protein:
MMP-12
Immunogen Range:
201-300/477
Clonality:
Polyclonal
Isotype:
IgG
Entrez Gene:
117033
Swiss Prot:
Q63341
Source:
KLH conjugated synthetic peptide derived from rat MMP12
Purification:
Purified by Protein A.
Storage Buffer:
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage:
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Background:
May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3 (By similarity).
PRODUCT SPECIFIC PUBLICATIONS
- Papakonstantinou et al. Acute exacerbations of COPD are associated with significant activation of matrix metalloproteinase 9 irrespectively of airway obstruction, emphysema and infection. (2015) Respir.Res. 16:78Read more>>
- Hashimoto K et al. Dietary DNA Attenuates the Degradation of Elastin Fibers in the Aortic Wall in Nicotine-Administrated Mice. (2018) Journal of Nutritional Science and Vitaminology, 64(4), 271–276. Read more>>
- Sukketsiri W et al. Isoflavone Ameliorated Oxidative Stress and Vascular Damages in Nicotine-Administrated Mice. J Oleo Sci. 2019 Dec 1;68(12):1241-1249.Read more>>
- ai S et al. Comparative analysis of pathophysiological parameters between emphysematous smokers and emphysematous patients with COPD. Sci Rep. 2020 Jan 15;10(1):420. Read more>>
- Mingzhu Xiao. et al. Nuciferine attenuates atherosclerosis by regulating the proliferation and migration of VSMCs through the Calm4/MMP12/AKT pathway in ApoE(-/-) mice fed with High-Fat-Diet. PHYTOMEDICINE. 2023 Jan;108:154536Read more>>
- Hirona Kugo. et al. Tricaprin can prevent the development of AAA by attenuating aortic degeneration. BIOMED PHARMACOTHER. 2023 Apr;160:114299Read more>>
- Xiaolan Guo. et al. Involvement of M2 macrophages polarization in PM2.5-induced COPD by upregulating MMP12 via IL4/STAT6 pathway. ECOTOX ENVIRON SAFE. 2024 Sep;283:116793Read more>>
VALIDATION IMAGES
Formalin-fixed and paraffin embedded mouse ovarian tissue labeled with Anti-MMP-12, Unconjugated (bs-1854R) followed by conjugation to the secondary antibody
Human Raji lysates probed with MMP12 Polyclonal Antibody, Unconjugated (bs-1854R) at 1:300 dilution and 4˚C overnight incubation. Followed by conjugated secondary antibody incubation at 1:10000 for 60 min at 37˚C.