DATASHEET
Host:
Rabbit
Target Protein:
Lamin B1
Immunogen Range:
361-460/586
Clonality:
Polyclonal
Isotype:
IgG
Entrez Gene:
4001
Swiss Prot:
P20700
Source:
KLH conjugated synthetic peptide derived from human Lamin B1
Purification:
Purified by Protein A.
Storage Buffer:
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage:
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Background:
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
PRODUCT SPECIFIC PUBLICATIONS
- Jiang Z et al. The Essential Oils and Eucalyptol From Artemisia vulgaris L. Prevent Acetaminophen-Induced Liver Injury by Activating Nrf2-Keap1 and Enhancing APAP Clearance Through Non-Toxic Metabolic Pathway. Front Pharmacol. 2019 Jul 25;10:782. Read more>>
- Wang Z et al. Aronia melanocarpa Prevents Alcohol-Induced Chronic Liver Injury via Regulation of Nrf2 Signaling in C57BL/6 Mice. Oxid Med Cell Longev. 2020 Jan 8;2020:4054520.Read more>>
- Zhao Y et al. Effect of mitochondrial quality control on the lycopene antagonizing DEHP-induced mitophagy in spermatogenic cells. Food Funct. 2020 Jul 22;11(7):5815-5826.Read more>>
- Xiaoyan Xia. et al. Ameliorative effect of white tea from 50-year-old tree of Camellia sinensis L. (Theaceae) on kidney damage in diabetic mice via SIRT1/AMPK pathway. J Ethnopharmacol. 2021 May;272:113919Read more>>
- Gi Ho Lee. et al. Impressic Acid Attenuates the Lipopolysaccharide-Induced Inflammatory Response by Activating the AMPK/GSK3/Nrf2 Axis in RAW264.7 Macrophages. Int J Mol Sci. 2021 Jan;22(2):762Read more>>
- Yuan Gao. et al. Lactobacillus plantarum Y44 alleviates oxidative stress by regulating gut microbiota and colonic barrier function in Balb/C mice with subcutaneous D-galactose injection. Food Funct. 2021 Jan;12(1):373-386Read more>>
- Feng Yanzhong. et al. Ulva prolifera Extract Alleviates Intestinal Oxidative Stress via Nrf2 Signaling in Weaned Piglets Challenged With Hydrogen Peroxide. Front Immunol. 2020 Oct;11:284Read more>>
- Lijin Guo. et al. Whole Transcriptome Analysis of Chicken Bursa Reveals Candidate Gene That Enhances the Hosts Immune Response to Coccidiosis. Front Physiol. 2020; 11: 573676Read more>>
- Xiping Yang. et al. The piperine derivative HJ105 inhibits A1-42-induced neuroinflammation and oxidative damage via the Keap1-Nrf2-TXNIP axis. Phytomedicine. 2021 Apr;:153571Read more>>
- Chun Dai. et al. A novel UV-curable extravascular stent to prevent restenosis of venous grafts. Compos Part B-Eng. 2021 Nov;225:10926Read more>>
- Wang, Huihui. et al. Anti-inflammatory and Antioxidant Effects of Pyrroloquinoline Quinone in L-NAME-Induced Preeclampsia-Like Rat Model. 2021 Sep 2Read more>>
- Xiao-Lin Huang. et al. Zoledronic acid inhibits osteoclastogenesis and bone resorptive function by suppressing RANKL?mediated NF?B and JNK and their downstream signalling pathways. Mol Med Rep. 2022 Feb;25(2):1-12Read more>>
- Jinsheng Li. et al. Micro/nano-topography Promotes Osteogenic Differentiation of Bone Marrow Stem Cells by Regulating Periostin Expression. COLLOID SURFACE B. 2022 Jul;:1127Read more>>
- Pu, Luya. et al. Laminar shear stress alleviates monocyte adhesion and atherosclerosis development via miR-29b-3p/CX3CL1 axis regulation. J CELL SCI. 2022 Jul;135(14)Read more>>
- iqi Han. et al. Effects of thiacloprid exposure on microbiotaCgutCliver axis: Multiomics mechanistic analysis in Japanese quails. J HAZARD MATER. 2023 Jan;442:130082Read more>>
- Chi Li. et al. Schisantherin D from Schisandra chinensis (Turcz.) Baill. exhibits anti-liver fibrosis capacity via modulating ETBR involved signaling, an in vitro and in vivo study. FITOTERAPIA. 2022 Oct;162:10529Read more>>
- Jia-Xin Wang. et al. Heme-oxygenase-1 as a target for phthalate-induced cardiomyocytes ferroptosis. ENVIRON POLLUT. 2023 Jan;317:120717Read more>>
- Ruonan Wang. et al. The role of mitochondrial dynamics imbalance in hexavalent chromium-induced apoptosis and autophagy in rat testis. CHEM-BIOL INTERACT. 2023 Apr;374:110424Read more>>
- Junling Gao. et al. Mechanisms underlying the synergistic effects of chuanxiong combined with Chishao on treating acute lung injury based on network pharmacology and molecular docking combined with preclinical evaluation. J ETHNOPHARMACOL. 2024 May;325:117862Read more>>
VALIDATION IMAGES
Rat brain lysate probed with Anti Lamin B [Nuclear Envelope Marker] Polyclonal Antibody, Unconjugated (bs-1840R) at 1:200 in 4˚C. Followed by conjugation to secondary antibody (bs-0295G-HRP) at 1:3000 90min in RT. Predicted band 64kD. Observed band size: 64kD
Molt-4 cells(black) were fixed with 4% PFA for 10min at room temperature,permeabilized with 90% ice-cold methanol for 20 min at -20℃, and incubated in 5% BSA blocking buffer for 30 min at room temperature. Cells were then stained with Lamin B1 Polyclonal Antibody(bs-1840R)at 1:50 dilution in blocking buffer and incubated for 30 min at room temperature, washed twice with 2% BSA in PBS, followed by secondary antibody(blue) incubation for 40 min at room temperature. Acquisitions of 20,000 events were performed. Cells stained with primary antibody (green), and isotype control (orange).