bs-1828R [Primary Antibody]
Plasminogen Polyclonal Antibody
www.biossusa.com
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Host: Rabbit

Target Protein: Plasminogen

Immunogen Range: 251-350/810


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 5340

Swiss Prot: P00747

Source: KLH conjugated synthetic peptide derived from human PLG

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Background:

Plasminogen is a plasma protein synthesised mostly in the liver. Plasma concentration is usually in the range of 70 to 200mg/l. Plasminogen is activated by tissue plasminogen activator, urokinase and streptokinase, to form plasmin. Activation results from the cleavage and release of the preactivation peptide. Angiostatin, an internal fragment of plasminogen, is a potent inhibitor of angiogenesis, which selectively inhibits endothelial cell proliferation. Angiostatin potently inhibits tumor growth and can maintain metastatic and primary tumors in a dormant state. It is defined by a balance of proliferation and apoptosis of the tumor cells and is composed of plasminogen first four cringle structures. This molecule is generated by proteolytic cleavage of plasminogen.

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
ELISA(1:500-1000)
IHC-P(1:200-400)

Predicted Molecular Weight: 53/87


Cross Reactive Species: Human

Predicted Cross Reactive Species: Mouse
Rat
Dog
Cow
Pig

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Yuemei LUO. et al. PGK1 succinylation modulates epileptic seizures and the blood-brain barrier. EXP ANIM TOKYO. 2023 Jun 01Read more>>
VALIDATION IMAGES

Paraformaldehyde-fixed, paraffin embedded human liver; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with Plasminogen Polyclonal Antibody, Unconjugated (bs-1828R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) instructions and DAB staining.