DATASHEET
Host:
Rabbit
Target Protein:
IRF9
Immunogen Range:
101-200/393
Clonality:
Polyclonal
Isotype:
IgG
Entrez Gene:
10379
Swiss Prot:
Q00978
Source:
KLH conjugated synthetic peptide derived from human IRF9
Purification:
Purified by Protein A.
Storage Buffer:
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage:
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Background:
Transcription factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
VALIDATION IMAGES
Formalin-fixed and paraffin embedded Human lung carcinoma tissue labeled with Anti-IRF9 Polyclonal Antibody, Unconjugated (bs-18169R) at 1:300 followed by conjugation to the secondary antibody and DAB staining
Formalin-fixed and paraffin embedded Human lung carcinoma labeled with Anti-IRF9 Polyclonal Antibody, Unconjugated (bs-18169R) at 1:300 followed by conjugation to the secondary antibody and DAB staining
Formalin-fixed and paraffin embedded human kidney tissue labeled with Rabbit Anti-IRF9 Polyclonal Antibody, Unconjugated (bs-18169R) at 1:200 followed by conjugation to the secondary antibody and DAB staining \n