bs-18129R-Cy5 [Conjugated Primary Antibody]
IKB alpha (Ser36) Polyclonal Antibody, Cy5 Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: IKB alpha (Ser36)

Modification Site: Ser36

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 4792

Swiss Prot: P25963

Source: KLH conjugated synthetic peptide derived from human phospho-IKB alpha (Ser36)

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.

Conjugation: Cy5

Excitation/ Emission: 625,650nm/670nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 35


Cross Reactive Species: Human
Mouse

Predicted Cross Reactive Species: Rat
Cow
Sheep
Pig
Rabbit

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Wang et al. Src Promotes Metastasis of Human Non-Small Cell Lung Cancer Cells through Fn14-Mediated NF-κB Signaling. (2018) Med.Sci.Monit. 24:1282-1294Read more>>
  • Zhu Feng. et al. Fungal Dysbiosis Aggravates Pouchitis in a Rat Model of Ileal Pouch Anal Anastomosis. Inflamm Bowel Dis. 2020 Nov;26(12):1831-1842Read more>>
  • Shiyan Chen. et al. Lactobacillus johnsonii L531 Alleviates the Damage Caused by Salmonella Typhimurium via Inhibiting TLR4, NF-B, and NLRP3 Inflammasome Signaling Pathways. Microorganisms. 2021 Sep;9(9):1983Read more>>
  • Zhao, Lei. et al. Lactobacillus plantarum S9 alleviates lipid profile, insulin resistance, and inflammation in high-fat diet-induced metabolic syndrome rats. SCI REP-UK. 2022 Sep;12(1):1-1Read more>>
  • Yan-Qing Xie. et al. Anti-inflammatory and analgesic effects of Streblus indicus. FRONT PHARMACOL. 2023; 14: 1249234Read more>>
  • Zhou Man. et al. MicroRNA miR-223 modulates NLRP3 and Keap1, mitigating lipopolysaccharide-induced inflammation and oxidative stress in bovine mammary epithelial cells and murine mammary glands. VET RES. 2023 Dec;54(1):1-14Read more>>
  • Li Ke. et al. The preventive effects of Lactobacillus casei 03 on Escherichia coli-induced mastitis in vitro and in vivo. J INFLAMM-LOND. 2024 Dec;21(1):1-9Read more>>
VALIDATION IMAGES