bs-1777R-HRP [Conjugated Primary Antibody]
Gastrin receptor/CCKBR Antibody, HRP Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: Gastrin receptor/GASR/CCKBR

Immunogen Range: 301-400/447


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 887

Swiss Prot: P32239

Source: KLH conjugated synthetic peptide derived from human Gastrin receptor

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism.

Conjugation: HRP

Excitation/ Emission: N/A

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
ELISA(1:500-1000)
IHC-P(1:200-400)
IHC-F(1:100-500)

Predicted Molecular Weight: 48


Cross Reactive Species: Mouse
Rat

Predicted Cross Reactive Species: Human
Cow
Rabbit

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Mohammad, Shahid, et al. "Functional compensation between cholecystokinin-1 and-2 receptors in murine paraventricular nucleus neurons." Journal of Biological Chemistry 287.47 (2012): 39391-39401.Read more>>
  • Mohammad et al. Functional compensation between cholecystokinin-1 and -2 receptors in murine paraventricular nucleus neurons. (2012) J.Biol.Che. 287:39391-401Read more>>
  • Lu-Lu Duan. et al. Spinal CCK contributes to somatic hyperalgesia induced by orofacial inflammation combined with stress in adult female rats. Eur J Pharmacol. 2021 Dec;913:174619Read more>>
  • Ting Xiang. et al. Spinal CCK1 receptors contribute to somatic pain hypersensitivity induced by malocclusion via a reciprocal neuron-glial signaling cascade. J PAIN. 2022 JuRead more>>
VALIDATION IMAGES