bs-1742R-FITC [Conjugated Primary Antibody]
PAN-CYP (3A4, 3A7, 3A5, and 3A9) Polyclonal Antibody, FITC Conjugated
www.biossusa.com
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DATASHEET

Host: Rabbit

Target Protein: CYP 3A4, 3A7, 3A5, and 3A9

Specificity: Will detect CYP 3A4, 3A7, 3A5, and 3A9

Immunogen Range: 18-120/503


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 1576

Source: KLH conjugated synthetic peptide derived from human CYP3A4

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Cytochromes P450 are a group of heme thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8 oxidation, omeprazole sulphoxidation, midazolam 1 hydroxylation and midazolam 4 hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. The enzyme also hydroxylates etoposide.

Conjugation: FITC

Excitation/ Emission: 494nm/518nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
FCM(1:20-100)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 55


Cross Reactive Species: Human
Mouse
Rat

Predicted Cross Reactive Species: Dog
Cow
Pig
Rabbit
Guinea Pig

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Ito, Junitsu, et al. ʺAscorbic acid reverses the prolonged anesthetic action of pentobarbital in Akr1a knockout mice.ʺ Life Sciences (2013).Read more>>
  • "Sun B et al. The interleukin-17 G-197A polymorphism is associated with cyclosporine metabolism and transplant rejection in liver transplant recipients. Pharmacogenomics. 2019 Feb 25."Read more>>
  • in Yang. et al. HPF Modulates the Differentiation of BMSCs into HLCs and Promotes the Recovery of Acute Liver Injury in Mice. INT J MOL SCI. 2023 Jan;24(6):5686Read more>>
VALIDATION IMAGES