DATASHEET
Host:
Rabbit
Target Protein:
KDM5A
Immunogen Range:
101-200/1690
Clonality:
Polyclonal
Isotype:
IgG
Entrez Gene:
5927
Swiss Prot:
P29375
Source:
KLH conjugated synthetic peptide derived from human KDM5A
Purification:
Purified by Protein A.
Storage Buffer:
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage:
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Background:
Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May stimulate transcription mediated by nuclear receptors. May be involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity).
VALIDATION IMAGES
Formalin-fixed and paraffin embedded human laryngeal tissue labeled with Rabbit Anti-KDM5A Polyclonal Antibody, Unconjugated (bs-16947R) at 1:200 followed by conjugation to the secondary antibody and DAB staining
Formalin-fixed and paraffin embedded human larynocarcinoma labeled with Anti-KDM5A Polyclonal Antibody, Unconjugated (bs-16947R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.