bs-1683R [Primary Antibody]
CNR1/CB1 Polyclonal Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: CNR1/CB1

Immunogen Range: 401-472/472


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 1268

Swiss Prot: P21554

Source: KLH conjugated synthetic peptide derived from human CNR-1

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Background:

Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.

Size: 100ul

Concentration: 1ug/ul

Applications: IHC-P(1:200-400)
IHC-F(1:100-500)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 52


Cross Reactive Species: Human
Rat

Predicted Cross Reactive Species: Mouse
Dog
Cow
Pig
Horse
Rabbit
Guinea Pig

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Xinna Wang. et al. Hejie Zhitong prescription promotes sleep and inhibits nociceptive transmission-associated neurotransmitter activity in a rodent migraine model. Chin Med-Uk. 2020 Dec;15(1):1-12Read more>>
  • enda L. K. Coles. et al. A microfluidic platform enables comprehensive gene expression profiling of mouse retinal stem cells. Lab Chip. 2021 OcRead more>>
  • Meenakshi Ahluwalia. et al. Altered endocannabinoid metabolism compromises the brain-CSF barrier and exacerbates chronic deficits after traumatic brain injury in mice. EXP NEUROL. 2023 Jan;:11432Read more>>
  • Damla Zeynep Doyuran. et al. The clinical and pathological significance of increased expression of the cannabinoid receptors CB-1R and CB-2R in patients with papillary thyroid carcinomas compared to benign thyroid lesions. INT J BIOL MARKER. ;()Read more>>
VALIDATION IMAGES

Formalin-fixed and paraffin embedded human cervical tissue labeled with Anti-CNR1 Polyclonal Antibody, Unconjugated (bs-1683R) at 1:200, followed by conjugation to the secondary antibody and DAB staining


Paraformaldehyde-fixed, paraffin embedded (Rat hippocampus); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Incubation with (CNR1) Polyclonal Antibody, Unconjugated (bs-1683R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.