DATASHEET
Host:
Rabbit
Target Protein:
CNR1/CB1
Immunogen Range:
401-472/472
Clonality:
Polyclonal
Isotype:
IgG
Entrez Gene:
1268
Swiss Prot:
P21554
Source:
KLH conjugated synthetic peptide derived from human CNR-1
Purification:
Purified by Protein A.
Storage Buffer:
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage:
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Background:
Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.
PRODUCT SPECIFIC PUBLICATIONS
- Xinna Wang. et al. Hejie Zhitong prescription promotes sleep and inhibits nociceptive transmission-associated neurotransmitter activity in a rodent migraine model. Chin Med-Uk. 2020 Dec;15(1):1-12Read more>>
- enda L. K. Coles. et al. A microfluidic platform enables comprehensive gene expression profiling of mouse retinal stem cells. Lab Chip. 2021 OcRead more>>
- Meenakshi Ahluwalia. et al. Altered endocannabinoid metabolism compromises the brain-CSF barrier and exacerbates chronic deficits after traumatic brain injury in mice. EXP NEUROL. 2023 Jan;:11432Read more>>
- Damla Zeynep Doyuran. et al. The clinical and pathological significance of increased expression of the cannabinoid receptors CB-1R and CB-2R in patients with papillary thyroid carcinomas compared to benign thyroid lesions. INT J BIOL MARKER. ;()Read more>>
VALIDATION IMAGES
Formalin-fixed and paraffin embedded human cervical tissue labeled with Anti-CNR1 Polyclonal Antibody, Unconjugated (bs-1683R) at 1:200, followed by conjugation to the secondary antibody and DAB staining
Paraformaldehyde-fixed, paraffin embedded (Rat hippocampus); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Incubation with (CNR1) Polyclonal Antibody, Unconjugated (bs-1683R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.