bs-1629R-Biotin [Conjugated Primary Antibody]
CXCR2/CD182 Polyclonal Antibody, Biotin Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: CXCR2/CD182

Immunogen Range: 316-360/360


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 3579

Swiss Prot: P25025

Source: KLH conjugated synthetic peptide derived from human CXCR2

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C for 12 months.

Background:

Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.

Conjugation: Biotin

Excitation/ Emission: N/A

Size: 100ul

Concentration: 1ug/ul

Applications: WB(WB 1:500-2000)
ELISA(ELISA 1:5000-10000)

Predicted Molecular Weight: 41


Cross Reactive Species: Human
Mouse
Rat

Predicted Cross Reactive Species: Dog
Cow
Pig
Horse
Rabbit
Guinea Pig

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Goetzenich, A. et al. "The role of macrophage migration inhibitory factor in anesthetic-induced myocardial preconditioning." PLoS ONE 9(3):e92827 (2014).Read more>>
  • Alexeev, Vitali, et al. "Chemotaxis-driven disease-site targeting of therapeutic adult stem cells in dystrophic epidermolysis bullosa." Stem Cell Research & Therapy 7.1 (2016): 124.Read more>>
  • Wang et al. Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression. (2016) Cancer.Disco. 6:80-95Read more>>
  • Li et al. NFATc1 regulates cell proliferation, migration, and invasion of ovarian cancer SKOV3 cells in vitro and in vivo. (2016) Oncol.Rep. 36:918-28Read more>>
  • Gunaseelan, Saravanan. et al. Pharmacological perturbation of CXCL1 signaling alleviates neuropathogenesis in a model of HEVA71 infection. Nat Commun. 2022 Feb;13(1):1-21Read more>>
  • Ting Shang. et al. Xuebijing injection inhibited neutrophil extracellular traps to reverse lung injury in sepsis mice via reducing Gasdermin D. FRONT PHARMACOL. 2022; 13: 1054176Read more>>
  • Guo, Zhi-chen. et al. Porphyromonas gingivalis promotes the progression of oral squamous cell carcinoma by activating the neutrophil chemotaxis in the tumour microenvironment. CANCER IMMUNOL IMMUN. 2022 Dec;:1-17Read more>>
  • Mengen Zhou. et al. Xuanfei Baidu Decoction regulates NETs formation via CXCL2/CXCR2 signaling pathway that is involved in acute lung injury. BIOMED PHARMACOTHER. 2023 May;161:11453Read more>>
  • Weiya Zeng. et al. Neutrophil Nanodecoys Inhibit Tumor Metastasis by Blocking the Interaction between Tumor Cells and Neutrophils. ACS NANO. 2024;XXXX(XXX):XXX-XXXRead more>>
  • Di Yan. et al. CXCR2, as a key regulatory gene of HDP-PG-1, maintains intestinal mucosal homeostasis. INT J BIOL MACROMOL. 2024 Jun;269:132025Read more>>
VALIDATION IMAGES