DATASHEET
Host:
Rabbit
Target Protein:
FIBIN
Immunogen Range:
101-200/211
Clonality:
Polyclonal
Isotype:
IgG
Entrez Gene:
387758
Swiss Prot:
Q8TAL6
Source:
KLH conjugated synthetic peptide derived from human FIBIN
Purification:
Purified by Protein A.
Storage Buffer:
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage:
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Background:
FIBIN (Fin bud initiation factor homolog) is a 211 amino acid protein involved in fin initiation in zebrafish. The human homolog is encoded by a gene that maps to chromosome 11, which makes up around 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. The blood disorders Sickle cell anemia and _ thalassemia are caused by HBB gene mutations. Wilms' tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11.
VALIDATION IMAGES
Mouse lung lysate probed with Rabbit Anti-FIBIN Polyclonal Antibody, Unconjugated (bs-16085R) at 1:300 in 4˚C. Followed by conjugation to secondary antibody (bs-0295G-HRP) at 1:5000 for 90min at RT.
Lane 1: Recombinant human FIBIN protein, N-Trx-His(bs-42187P) probed with FIBIN Polyclonal Antibody, Unconjugated (bs-16085R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.