bs-1604R [Primary Antibody]
ABCB5 Polyclonal Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: ABCB5

Immunogen Range: 841-883/1257


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 340273

Swiss Prot: Q2M3G0

Source: KLH conjugated synthetic peptide derived from human ABCB5

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Background:

Drug efflux transporter present in a number of stem cells that acts as a regulator of cellular differentiation. Able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Specifically present in limbal stem cells, where it plays a key role in corneal development and repair.

Size: 100ul

Concentration: 1ug/ul

Applications: ELISA(1:500-1000)
IHC-P(1:200-400)
IHC-F(1:100-500)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 89/138


Cross Reactive Species: Mouse

Predicted Cross Reactive Species: Human
Rat
Dog
Cow
Horse

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Kaushik, Gaurav, et al. "Honokiol inhibits melanoma stem cells by targeting notch signaling." Molecular carcinogenesis (2014).Read more>>
  • Hardt, Olaf, et al. "SSEA4 AND ST3GAL2 AS CHEMOTHERAPEUTIC DRUG RESPONSE BIOMARKERS." U.S. Patent No. 20,150,316,556. 5 Nov. 2015.Read more>>
  • Julia Riedl. et al. ABCB5+ dermal mesenchymal stromal cells with favorable skin homing and local immunomodulation for recessive dystrophic epidermolysis bullosa treatment. 2021 Mar 01Read more>>
  • Anna Kusienicka. et al. Heme Oxygenase-1 Has a Greater Effect on Melanoma Stem Cell Properties Than the Expression of Melanoma-Initiating Cell Markers. Int J Mol Sci. 2022 Jan;23(7):3596Read more>>
VALIDATION IMAGES

Formalin-fixed and paraffin embedded mouse melanoma labeled with Rabbit Anti ABCB5 Polyclonal Antibody, Unconjugated (bs-1604R) at 1:200 followed by conjugation to the secondary antibody and DAB staining