bs-15390R-A350 [Conjugated Primary Antibody]
GPR37L1 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated
www.biossusa.com
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Host: Rabbit

Target Protein: GPR37L1

Immunogen Range: 101-200/481


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 9283

Swiss Prot: O60883

Source: KLH conjugated synthetic peptide derived from human GPR37L1

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Background:

G-protein coupled receptor. Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade. However, other studies have shown that prosaposin does not increase activity. It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha. Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway. Regulates baseline blood pressure in females and protects against cardiovascular stress in males. Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity.

Conjugation: ALEXA FLUOR® 350

Excitation/ Emission: 346nm/442nm

Size: 100ul

Concentration: 1ug/ul

Applications: IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 50


Predicted Cross Reactive Species: Human
Mouse

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Sonjoy SARKAR. et al. Expression of the G protein-coupled receptor (GPR) 37 and GPR37L1 in the mouse digestive system. 2020 Nov 18Read more>>
  • Kai Kitamura. et al. Expression patterns of prosaposin and its receptors, G protein-coupled receptor (GPR) 37 and GPR37L1, in the mouse olfactory organ. TISSUE CELL. 2023 Jun;82:102093Read more>>
  • Sangsu Bang. et al. Satellite glial GPR37L1 and its ligand maresin 1 regulate potassium channel signaling and pain homeostasis. J CLIN INVEST. 2024 MaRead more>>