bs-1475R-Cy7 [Conjugated Primary Antibody]
Gremlin 1 Polyclonal Antibody, Cy7 Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: Gremlin 1

Immunogen Range: 101-184/184


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 26585

Swiss Prot: O60565

Source: KLH conjugated synthetic peptide derived from human gremlin 1

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Acts as inhibitor of monocyte chemotaxis (By similarity).

Conjugation: Cy7

Excitation/ Emission: 743nm/767nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 21


Cross Reactive Species: Human
Mouse
Rat

Predicted Cross Reactive Species: Dog
Cow
Horse
Chicken
Rabbit

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Wellbrock, Jasmin, et al. "Overexpression of Gremlin-1 in Patients with Loeys-Dietz Syndrome: Implications on Pathophysiology and Early Disease Detection." PLoS one 9.8 (2014): e104742.Read more>>
  • KAWAGUCHI, Kenichiro, et al. "Role of Gremlins in the Aortic Arch of Spontaneously Hypertensive and Hyperlipidemic Rats." The Showa University Journal of Medical Sciences 28.2 (2016): 89-99.Read more>>
  • He H et al. Low oxygen concentrations improve yak oocyte maturation and enhance the developmental competence of preimplantation embryos. Theriogenology. 2020 Oct 15;156:46-58.Read more>>
  • Yoichiro Aoshima. et al. Gremlin-1 for the Differential Diagnosis of Idiopathic Pulmonary Fibrosis Versus Other Interstitial Lung Diseases: A Clinical and Pathophysiological Analysis. 2021 Mar 26Read more>>
  • Xiaoyue Guan. et al. The possible role of Gremlin1 in inflammatory apical periodontitis. ARCH ORAL BIOL. 2023 Nov;:105848Read more>>
  • Takahashi Ikufumi. et al. Histological and immunohistochemical analyses of articular cartilage during onset and progression of pre- and early-stage osteoarthritis in a rodent model. SCI REP-UK. 2024 May;14(1):1-1Read more>>
  • Xiao-yue Guan. et al. Blocking Gremlin1 inhibits M1 macrophage polarization through Notch1/Hes1 signaling pathway in apical periodontitis. IMMUNOPHARM IMMUNOT. 2024 27Read more>>