bs-14667R-APC

DATASHEET

Host: Rabbit

Target Protein: EXOSC4

Immunogen Range: 51-150/245

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 54512

Swiss Prot: Q9NPD3

Source: KLH conjugated synthetic peptide derived from human EXOSC4

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

The exosome is a multisubunit complex composed of several highly conserved subunits, some of which are 3 to 5 exoribonucleases. The complex is involved in a variety of cellular processes and is responsible for degrading unstable mRNAs that contain AU-rich (ARE) elements in their untranslated 3 region. EXOSC4 (exosome component 4), also known as SKI6, RRP41 or p12A, is a 245 amino acid protein that localizes to both the nucleus and the cytoplasm and shares 96% sequence identity with its mouse counterpart. Functioning as a component of the exosome complex, EXOSC4 exhibits 3'-5' exonuclease activity and is required for the 3'-processing of 7S pre-RNA to mature 5.8S rRNA. The gene encoding EXOSC4 maps to human chromosome 8, which consists of nearly 146 million base pairs, houses more than 800 genes and is associated with a variety of diseases and malignancies.

Conjugation: APC

Excitation/ Emission: 650nm/660nm

Size: 100ul

Concentration: 1ug/ul

Applications: IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 26

Cross Reactive Species: Mouse

Predicted Cross Reactive Species: Human
Rat
Dog
Cow
Sheep
Pig
Horse

For research use only. Not intended for diagnostic or therapeutic use.