bs-1459R-BF405 [Conjugated Primary Antibody]
IL-6R Beta/CD130/gp130 Antibody, AbBy Fluor® 405 Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: IL-6R Beta/CD130/gp130

Immunogen Range: 651-750/917


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 16195

Swiss Prot: Q00560

Source: KLH conjugated synthetic peptide derived from mouse IL6R beta

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development.

Conjugation: AbBy Fluor® 405

Excitation/ Emission: 401nm/421nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
FCM(1:20-100)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 99


Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Prystaz, Katja, et al. "Distinct effects of interleukin-6 classic and trans-signaling in bone fracture healing." The American Journal of Pathology.Read more>>
  • Zhou et al. Interleukin‑6 induces an epithelial‑mesenchymal transition phenotype in human adamantinomatous craniopharyngioma cells and promotes tumor cell migration. (2017) Mol.Med.Re. 15:4123-4131Read more>>
  • Iwamura H et al. Caloric restriction reduces basal cell proliferation and results in the deterioration of neuroepithelial regeneration following olfactotoxic mucosal damage in mouse olfactory mucosa. Cell Tissue Res. 2019 Jun 6. Read more>>
  • Weber AE et al. Modulation of Hedgehog Signaling by Kappa Opioids to Attenuate Osteoarthritis. Arthritis Rheumatol. 2020 Aug;72(8):1278-1288.Read more>>
  • Obi, Andrea T.. et al. Experimental venous thrombus resolution is driven by IL-6 mediated monocyte actions. SCI REP-UK. 2023 Feb;13(1):1-12Read more>>
VALIDATION IMAGES