bs-1434R-BF405 [Conjugated Primary Antibody]
IGFBP3 Polyclonal Antibody, AbBy Fluor® 405 Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: IGFBP3

Immunogen Range: 186-292/292


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 3486

Swiss Prot: P17936

Source: KLH conjugated synthetic peptide derived from human IGFBP3

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.

Conjugation: AbBy Fluor® 405

Excitation/ Emission: 401nm/421nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 30-35


Cross Reactive Species: Human
Rat

Predicted Cross Reactive Species: Mouse

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Yuan, Qing, et al. "Docetaxel-loaded solid lipid nanoparticles suppress breast cancer cells growth with reduced myelosuppression toxicity." International Journal of Nanomedicine 9 (2014): 4829.Read more>>
  • Liu et al. Effects of insulin-like growth factor binding protein 3 on apoptosis of cutaneous squamous cell carcinoma cells. (2018) Onco.Targets.Ther. 11:6569-6577Read more>>
  • Diao S et al. IGF2 enhanced the osteo‐/dentinogenic and neurogenic differentiation potentials of stem cells from apical papilla. J Oral Rehabil. 2019 Jul 10. Read more>>
  • Suwei Chen. et al. Insulin\like growth factor\binding protein 3 inhibits angiotensin II\induced aortic smooth muscle cell phenotypic switch and matrix metalloproteinase expression. Exp Physiol. 2020 Nov;105(11):1827-1839Read more>>
  • Juil Kim. et al. Mucosal ribosomal stress-induced PRDM1 promotes chemoresistance via stemness regulation. Commun Biol. 2021 May;4(1):1-14Read more>>
  • Nanchi Zhang. et al. Yak IGFBP3 promotes hepatocyte proliferation through PI3K-Akt signaling pathway. GENE. 2024 Jul;917:14846Read more>>
VALIDATION IMAGES