bs-1356R-Cy3 [Conjugated Primary Antibody]
Integrin Alpha V + Beta 5 Antibody, Cy3 Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: Integrin Alpha V + Beta 5

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 3685

Swiss Prot: P06756

Source: KLH conjugated synthetic peptide derived from human Integrin beta 5 and Integrin alpha V

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Conjugation: Cy3

Excitation/ Emission: 512,550nm/570,615nm

Size: 100ul

Concentration: 1ug/ul

Applications: FCM(1:20-100)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 88/121


Cross Reactive Species: Human
Mouse

Predicted Cross Reactive Species: Rat

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Mondal, Goutam, Sugata Barui, and Arabinda Chaudhuri. "The relationship between the cyclic-RGDfK ligand and ??v??3 integrin receptor."iomaterials (2013).iiRead more>>
  • Chen, Ming, et al. "Periostin activates pathways involved in epithelial-mesenchymal transition in adamantinomatous craniopharyngioma." Journal of the Neurological Sciences (2015).Read more>>
  • Nande, Rounak Paramjeet, "Investigation Of Ultrasound Targeted Microbubbles As A Therapeutic Gene Delivery System For Prostate Cancer" (2015). Theses, Dissertations and Capstones. Paper 915.Read more>>
  • Bian, Qin, et al. "Mechanosignaling activation of TGFβ maintains intervertebral disc homeostasis." Bone Research 5 (2017): 17008.Read more>>
  • Tomohiro Yokotaet al. Type V Collagen in Scar Tissue Regulates the Size of Scar after Heart Injury. Cell. 2020 Aug 6;182(3):545-562.e23.Read more>>
  • Yusuke Mochizuki. et al. Telomerase-specific oncolytic immunotherapy for promoting efficacy of PD-1 blockade in osteosarcoma. 2020 Nov 05Read more>>
  • Satoru Kuriu. et al. Slicing Spheroids in Microfluidic Devices for Morphological and Immunohistochemical Analysis. Micromachines-Basel. 2020 May;11(5):48Read more>>
  • Tatiana Hurtado de Mendoza. et al. Tumor-penetrating therapy for 5 integrin-rich pancreas cancer. Nat Commun. 2021 Mar;12(1):1-13Read more>>
  • Gehua Zhen. et al. Mechanical stress determines the configuration of TGF activation in articular cartilage. Nat Commun. 2021 Mar;12(1):1-16Read more>>
  • Satoru Kuriu. et al. Microfluidic Device Using Mouse Small Intestinal Tissue for the Observation of Fluidic Behavior in the Lumen. Micromachines-Basel. 2021 Jun;12(6):692Read more>>
  • Guo Xiaoye. et al. The influence of a modified p53 C-terminal peptide by using a tumor-targeting sequence on cellular apoptosis and tumor treatment. APOPTOSIS. 2023 Dec;:1-17Read more>>
  • Yongchang Yang. et al. The CEBPB+ glioblastoma subcluster specifically drives the formation of M2 tumor-associated macrophages to promote malignancy growth. THERANOSTICS. 2024; 14(10): 41074126Read more>>
  • Sidorenko Valeria. et al. Targeting vascular disrupting agent-treated tumor microenvironment with tissue-penetrating nanotherapy. SCI REP-UK. 2024 Jul;14(1):1-16Read more>>
VALIDATION IMAGES