bs-13347R [Primary Antibody]
Gametogenetin Polyclonal Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: Gametogenetin

Immunogen Range: 5-100/652


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 199720

Source: KLH conjugated synthetic peptide derived from human GGN/Gametogenetin

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Background:

Gametogenetin is a 652 amino acid protein that is primarily expressed in testis and ovary. Interacting with POG (proliferation of germ cells), GGNBP1 and LCRG1, gametogenetin is likely involved in spermatogenesis. Gametogenetin exists as three alternatively spliced isoforms commonly known as gametogenetin protein 1 (GGN1), gametogenetin protein 2 (GGN2) and gametogenetin protein 3 (GGN3), which localize to nuclear membrane, cytoplasm and nucleus/nucleoli, respectively. GGN1 contains two transmembrane domains in its N-terminal half and 2 C-terminal arginine- and lysine-rich nucleolar targeting sequences. GGN1 and GGN3 are likely linked to germ cell development and both GGN1 and GGN2 may be involved in cell trafficking.

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
ELISA(1:500-1000)
IHC-P(1:200-400)
IHC-F(1:100-500)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)
ICC(1:100-500)

Predicted Molecular Weight: 67


Cross Reactive Species: Human
Rat

Predicted Cross Reactive Species: Mouse
Dog
Cow
Sheep
Pig

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Liu Z et al. GGN Promotes Tumorigenesis by Regulating Proliferation and Apoptosis in Colorectal Cancer. Pathol Oncol Res. 2019 Feb 5.Read more>>
  • Suresh Bugide. et al. ALK inhibitors suppress HCC and synergize with anti-PD-1 therapy and ABT-263 in preclinical models. ISCIENCE. 2024 Apr 23Read more>>
VALIDATION IMAGES

Formalin-fixed and paraffin embedded rat testis labeled with Rabbit Anti-GGN/Gametogenetin Polyclonal Antibody, Unconjugated (bs-13347R) at 1:200 followed by conjugation to the secondary antibody and DAB staining\n


A549 Cell lysates probed with Gametogenetin Polyclonal Antibody, unconjugated (bs-13347R) at 1:300 overnight at 4°C followed by a conjugated secondary antibody for 60 minutes at 37°C.