bs-13107R [Primary Antibody]
ESAT6 Polyclonal Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: ESAT6

Immunogen Range: 21-95/95


Clonality: Polyclonal

Isotype: IgG

Source: KLH conjugated synthetic peptide derived from Mycobacterium tuberculosis ESAT6

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Background:

Mycobacterium tuberculosis is a slow-growing obligate aerobic bacillus that causes most cases of tuberculosis (TB). It is a small, rod-like microbe that can withstand weak disinfectants and survive in a dry state for weeks, but can only grow within a host organism. M. tuberculosis has a thick waxy cell wall that is responsible for the typical caseous granuloma formation in tuberculosis. ESAT6 is a protein secreted by M. tuberculosis that induces a strong immune response in infected organisms, making it a strong candidate for the development of a vaccine against tuberculosis. ESAT6 may also be useful in the detection of the disease. Deletion of the ESAT6 gene leads to the loss of virulence of M. tuberculosis.

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
ELISA(1:500-1000)
IHC-P(1:200-400)
IHC-F(1:100-500)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)
ICC(1:100-500)

Predicted Molecular Weight: 10


Cross Reactive Species: Mouse
Bacteria
(Mycobacterium)

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Koyama, Yoshiyuki, et al. "Exosomes derived from tumor cells genetically modified to express Mycobacterium tuberculosis antigen: a novel vaccine for cancer therapy." Biotechnology Letters (2016): 1-10.Read more>>
  • Tomoko Ito. et al. Microbial Antigen-Presenting Extracellular Vesicles Derived from Genetically Modified Tumor Cells Promote Antitumor Activity of Dendritic Cells. Pharmaceutics. 2021 Jan;13(1):57Read more>>
  • Xueqian Chen. et al. Diagnostic value of tuberculosis-specific antigens ESAT-6 and CFP10 in lymph node tuberculosis. HELIYON. 2024 Apr;1Read more>>