bs-1305R-Cy3 [Conjugated Primary Antibody]
CCR7/CD197 Polyclonal Antibody, Cy3 Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: CCR7/CD197

Immunogen Range: 25-59/379


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 12775

Swiss Prot: P47774

Source: KLH conjugated synthetic peptide derived from mouse CCR7

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

CCR7 is a member of the G protein coupled receptor family (subfamily : chemokine). This receptor was identified as a gene induced by the Epstein Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. CCR7 has been reported to be expressed in blood, bone marrow, lymph node, and intestine. It is particularly expressed in lymphoid tissues and in activated B and T lymphocytes and has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. ESTs have been isolated from blood, embryo, lymph node, and thymus libraries.

Conjugation: Cy3

Excitation/ Emission: 512,550nm/570,615nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
FCM(1:20-100)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 42


Cross Reactive Species: Human
Mouse
Rat
Sheep

Predicted Cross Reactive Species: Dog

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • en Menachem-Zidon O et al. Age-associated differences in macrophage response in a vaginal wound healing rat model. Int Urogynecol J. 2020 Feb 27.Read more>>
  • Blomgran, Parmis, et al. "A possible link between loading, inflammation and healing: Immune cell populations during tendon healing in the rat." Scientific Reports 6 (2016): 29824.Read more>>
  • "Li, Xuelu, et al. ""High Expression of CCR7 Predicts Lymph Node Metastasis and Good Prognosis in Triple Negative Breast Cancer."" Cellular Physiology and Biochemistry 43.2 (2017): 531-539. "Read more>>
  • Dijk et al. Systematic Evaluation of the Cellular Innate Immune Response During the Process of Human Atherosclerosis. (2016) J.Am.Heart.Assoc. 5 Read more>>
  • Expression of Pref-1 and Related Chemokines during theDevelopment of Rat Mesenteric Lymph Nodes.(2018)Biomed Environ Sci.ul;31(7):507-514. Read more>>
  • Liu Y et al. Isolation and characterization of ovine monocyte-derived macrophages from peripheral blood.(2018)Vet Immunol Immunopathol. Nov;205:83-92. Read more>>
  • Li Y et al. Role of CCR7 on dendritic cell‑mediated immune tolerance in the airways of allergy‑induced asthmatic rats. Mol Med Rep. 2019 Sep 20. Read more>>
  • Ben Menachem-Zidon O et al. Age-associated differences in macrophage response in a vaginal wound healing rat model. Int Urogynecol J. 2020 Feb 27.Read more>>
  • Liu Xingdan. et al. Hydroxyapatite composited PEEK with 3D porous surface enhances osteoblast differentiation through mediating NO by macrophage. Regen Biomater. 2021 DecRead more>>
  • Hao, Yanan. et al. Gut microbiota-testis axis: FMT improves systemic and testicular micro-environment to increase semen quality in type 1 diabetes. MOL MED. 2022 Dec;28(1):1-17Read more>>
  • Zheng Xinhui. et al. Effect of micro/nano-sheet array structures on the osteo-immunomodulation of macrophages. REGEN BIOMATER. 2022 OcRead more>>
  • Hanhan Fang. et al. Gut-Spleen Axis: Microbiota via Vascular and Immune Pathways Improve Busulfan-Induced Spleen Disruption | mSphere. MSPHERE. 2022 DecRead more>>
  • Chengetai R Mahomva. et al. Chemokine CCL19 and Its Receptors CCR7 and CCRL1 in Chronic Rhinosinusitis. J INFLAMM RES. 2024 May;17:2991-3002Read more>>
  • Ao Wang. et al. Inhibition of NLRP3 inflammasome ameliorates LPS-induced neuroinflammatory injury in mice via PINK1/Parkin pathway. NEUROPHARMACOLOGY. 2024 Oct;257:110063Read more>>
VALIDATION IMAGES