DATASHEET
Host:
Rabbit
Target Protein:
CYP1B1
Immunogen Range:
441-543/543
Clonality:
Polyclonal
Isotype:
IgG
Entrez Gene:
1545
Swiss Prot:
Q16678
Source:
KLH conjugated synthetic peptide derived from human CYP1B1
Purification:
Purified by Protein A.
Storage Buffer:
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage:
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Background:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, retinoid and xenobiotics. Preferentially oxidizes 17beta-estradiol to the carcinogenic 4-hydroxy derivative, and a variety of procarcinogenic compounds to their activated forms, including polycyclic aromatic hydrocarbons. Promotes angiogenesis by removing cellular oxygenation products, thereby decreasing oxidative stress, release of antiangiogenic factor THBS2, then allowing endothelial cells migration, cell adhesion and capillary morphogenesis. These changes are concommitant with the endothelial nitric oxide synthase activity and nitric oxide synthesis. Plays an important role in the regulation of perivascular cell proliferation, migration, and survival through modulation of the intracellular oxidative state and NF-kappa-B expression and/or activity, during angiogenesis. Contributes to oxidative homeostasis and ultrastructural organization and function of trabecular meshwork tissue through modulation of POSTN expression.
Conjugation:
AbBy Fluor® 555
Excitation/ Emission:
553nm/568nm
Size:
100ul
Concentration:
1ug/ul
Applications:
WB(1:300-5000)
61
Mouse
Predicted Cross Reactive Species:
Human
Rat
Dog
Horse
For research use only. Not intended for diagnostic or therapeutic use.