bs-12862R-Cy7 [Conjugated Primary Antibody]
CTXB/beta subunit Cholera Toxin Antibody, Cy7 Conjugated
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Host: Rabbit

Target Protein: CTXB/beta subunit Cholera Toxin

Immunogen Range: 51-124/124


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 2613962

Source: KLH conjugated synthetic peptide derived from CTXB/beta subunit Cholera Toxin

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

The B subunit of cholera toxin (CtxB) binds to a GM1-ganglioside receptor, a ubiquitous glycolipid cell surface receptor. This binding is widely accepted to initiate toxin action by triggering uptake and delivery of the toxin A subunit into cells. The beta chain has no toxic activity by itself. The holotoxin consists of a pentameric ring of B subunits whose central pore is occupied by the A subunit. The A subunit contains two chains, A1 and A2, linked by a disulfide bridge. The A subunit (and Cholera toxin) activates the adenylate cyclase enzyme in cells of the intestinal mucosa leading to increased levels of intracellular cAMP.

Conjugation: Cy7

Excitation/ Emission: 743nm/767nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 12


Cross Reactive Species: Rat
Others
(Cholera Toxin Subunit B)

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Tanaka, Koichi, et al. "Possible role of the myelinated neural network in the parietal peritoneum in rats as a mechanoreceptor." The Anatomical Record (2017).Read more>>
  • Zhao, Yuanyuan. et al. ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimers disease models. Nat Commun. 2022 Mar;13(1):1-2Read more>>