bs-12854R-Cy7

DATASHEET

Host: Rabbit

Target Protein: beta Catenin Ser37

Modification Site: Ser37

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 1499

Source: KLH conjugated synthetic phosphopeptide derived from human beta Catenin around the phosphorylation site of Ser37

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Oct 2009].

Conjugation: Cy7

Excitation/ Emission: 743nm/767nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 86

Cross Reactive Species: Human
Mouse
Rat

Predicted Cross Reactive Species: Pig
Chicken
Rabbit

For research use only. Not intended for diagnostic or therapeutic use.