bs-1232R [Primary Antibody]
GABA A Receptor alpha 1 Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: GABA A Receptor alpha 1

Immunogen Range: 301-450/456


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 2554

Swiss Prot: P14867

Source: KLH conjugated synthetic peptide derived from human GABRA1

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Background:

Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity).

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
ELISA(1:500-1000)
IHC-P(1:200-400)
IHC-F(1:100-500)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 52


Cross Reactive Species: Mouse
Rat

Predicted Cross Reactive Species: Human
Dog
Cow
Horse
Chicken

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Kumar, Subodh. et al. Synaptosome microRNAs regulate synapse functions in Alzheimers disease. NPJ GENOM MED. 2022 Aug;7(1):1-15Read more>>
  • Sharma Bhupender. et al. MicroRNA-502-3p regulates GABAergic synapse function in hippocampal neurons. NEURAL REGEN RES. 2024 Mar;:10.4103/NRR.NRRRead more>>
VALIDATION IMAGES

Mouse brain lysates probed with Rabbit Anti-GABA A Receptor alpha 1 Polyclonal Antibody, Unconjugated (bs-1232R) at 1:300 overnight at 4˚C. Followed by conjugation to secondary antibody (bs-0295G-HRP) at 1:500 for 90 min at RT.


Formalin-fixed and paraffin embedded rat brain tissue labeled with Anti-GABRA1 Polyclonal Antibody, Unconjugated(bs-1232R) at 1:200 followed by conjugation to the secondary antibody and DAB staining


Lane 1: Mouse Cerebrum lysates; Lane 2:Rat Cerebllum lysates probed with GABA A Receptor alpha 1 Polyclonal Antibody, Unconjugated (bs-1232R) at 1:1000 dilution and 4˚C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.