DATASHEET
Host:
Rabbit
Target Protein:
SOX17
Clonality:
Polyclonal
Isotype:
IgG
Entrez Gene:
64321
Source:
KLH conjugated synthetic peptide derived from human SOX17
Purification:
Purified by Protein A.
Storage Buffer:
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage:
Store at -20°C for 12 months.
Background:
Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.
VALIDATION IMAGES
Formalin-fixed and paraffin embedded rat uterus labeled with Anti-SOX17 Polyclonal Antibody, Unconjugated (bs-12205R) at 1:200 followed by conjugation to the secondary antibody and DAB staining\n
Lane 1: Mouse Heart tissue lysates; Lane 2: Mouse Ovary tissue lysates probed with SOX17 Polyclonal Antibody, Unconjugated (bs-12205R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.