DATASHEET
Host:
Rabbit
Target Protein:
TLR5
Immunogen Range:
701-810/873
Clonality:
Polyclonal
Isotype:
IgG
Entrez Gene:
53791
Swiss Prot:
Q9JLF7
Source:
KLH conjugated synthetic peptide derived from mouse TLR5
Purification:
Purified by Protein A.
Storage Buffer:
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage:
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Background:
Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).
PRODUCT SPECIFIC PUBLICATIONS
- Hao, Jing, et al. "rFliC prolongs allograft survival in association with the activation of recipient Tregs in a TLR5-dependent manner." Cellular & molecular immunology (2013).Read more>>
- Sun, Hukui, et al. "Non‐invasive imaging of allogeneic transplanted skin graft by 131I‐anti‐TLR5 mAb." Journal of Cellular and Molecular Medicine (2014).Read more>>
- Sun, H., et al. "In vivo Toll‐like receptor 5 (TLR5) imaging with radiolabeled anti‐TLR5 monoclonal antibody in rapamycin‐treated mouse allogeneic skin transplantation model." Transplant Infectious Disease (2015).Read more>>
- Li, Chengcheng, et al. "Phycocyanin attenuates pulmonary fibrosis via the TLR2-MyD88-NF-κB signaling pathway." Scientific Reports 7 (2017).Read more>>
- Shi D et al. TLR5: A prognostic and monitoring indicator for triple-negative breast cancer. Cell Death Dis. 2019 Dec 18;10(12):954.Read more>>
- Wang Ruibiao. et al. Effects of exosomes derived from Trichinella spiralis infective larvae on intestinal epithelial barrier function. VET RES. 2022 Dec;53(1):1-11Read more>>
VALIDATION IMAGES
Lane 1: Mouse Liver; Lane 2: Mouse Ovary; 40ug loaded in each lane; Probed with TLR5 Polyclonal Antibody, unconjugated (bs-1197R) at 1:1000 overnight at 4°C followed by a conjugated secondary antibody for 60 minutes at 37°C.
Lane 1: Mouse Raw264.7 Cells; Lane 2: Human Hela Cells; 30ug loaded in each lane; Probed with TLR5 Polyclonal Antibody, unconjugated (bs-1197R) at 1:1000 overnight at 4°C followed by a conjugated secondary antibody for 60 minutes at 37°C.