bs-1183R
[Primary Antibody]
IL-17 Polyclonal Antibody
DATASHEET
Host: Rabbit
Target Protein: IL-17
Immunogen Range: 85-150/150
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 301289
Swiss Prot: Q61453
Source: KLH conjugated synthetic peptide derived from rat IL-17
Purification: Purified by Protein A.
Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Background:
Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts.
Size: 100ul
Concentration: 1ug/ul
Applications:
WB(1:300-5000)
ELISA(1:500-1000)
FCM(1:20-100)
IHC-P(1:200-400)
IHC-F(1:100-500)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)
Predicted Molecular Weight: 15
Cross Reactive Species:
Human
Mouse
Rat
For research use only. Not intended for diagnostic or therapeutic use.
PRODUCT SPECIFIC PUBLICATIONS
- Wang N et al. CD226 attenuates Treg suppressive capacity via CTLA-4 and TIGIT during EAE. Immunol Res. 2019 Dec;67(6):486-496.Read more>>
- Ishida, Waka, et al. "Inhibition of very late antigen-4 and leukocyte function-associated antigen-1 in experimental autoimmune uveoretinitis." Clinical Immunology (2014).Read more>>
- Venkatasubramanian, Sambasivan, et al. "Tissue factor expression by myeloid cells contributes to protective immune response against Mycobacterium tuberculosis infection." European Journal of Immunology (2015).Read more>>
- Yang, Lijuan, et al. "Effect of IL-17 in the development of colon cancer in mice." Oncology Letters 12.6 (2016): 4929-4936.Read more>>
- Chen, Baiwen, et al. "Effects of 1, 25-dihydroxyvitamin D3 in an ovalbumin-induced allergic rhinitis model." International Immunopharmacology 47 (2017): 182-189.Read more>>
- Liao, Yanxi, et al. "Promoting effects of IL‑23 on myocardial ischemia and reperfusion are associated with increased expression of IL‑17A and upregulation of the JAK2‑STAT3 signaling pathway." Molecular Medicine Reports.Read more>>
- Liao, Yanxi, et al. "Promoting effects of IL‑23 on myocardial ischemia and reperfusion are associated with increased expression of IL‑17A and upregulation of the JAK2‑STAT3 signaling pathway." Molecular Medicine Reports.Read more>>
- Yi et al. Vagus nerve stimulation attenuates myocardial ischemia/reperfusion injury by inhibiting the expression of interleukin-17A. (2016) Exp.Ther.Me. 11:171-176Read more>>
- Zheng X et al. Dendritic cells and Th17/Treg ratio play critical roles in pathogenic process of chronic obstructive pulmonary disease. (2018) Biomedicine & Pharmacotherapy.108,1141–1151. Read more>>
- Xiong Y et al. Functions of T-cell subsets and their related cytokines in the pathological processes of autoimmune encephalomyelitic mice.(2018) Int J Clin Exp Pathol;11(10):4817-4826.Read more>>
- Qiu et al. Therapeutic Potential of Pien Tze Huang on Experimental Autoimmune Encephalomyelitis Rat. (2018) J.Immunol.Res. 2018:2952471Read more>>
- Pu J et al. FGF-7 facilitates the process of psoriasis by inducing TNF-α expression in HaCaT cells. Acta Biochim Biophys Sin (Shanghai). 2019 Sep 6;51(10):1056-1063. Read more>>
- Wang N et al. CD226 attenuates Treg suppressive capacity via CTLA-4 and TIGIT during EAE. Immunol Res. 2019 Dec;67(6):486-496.Read more>>
- L.H. Frommherz. et al. Secukinumab for the treatment of SAM syndrome associated with desmoglein\1 deficiency. 2020 Nov 18Read more>>
- Qingqing Chen. et al. Coptis chinensis Franch polysaccharides provide a dynamically regulation on intestinal microenvironment, based on the intestinal flora and mucosal immunity. J Ethnopharmacol. 2021 Mar;267:113542Read more>>
- Emin Kaymak. et al. Thymoquinone has a neuroprotective effect against inflammation, oxidative stress, and endoplasmic reticulum stress in the brain cortex, medulla, and hippocampus due to doxorubicin. 2021 Aug 15Read more>>
- Qingqing Liu. et al. Probiotics alleviate autoimmune hepatitis in mice through modulation of gut microbiota and intestinal permeability. J Nutr Biochem. 2021 Sep;:108863Read more>>
- Zhou Yonglong. et al. Mechanism of Catechol-O-methyltransferase Regulating Orofacial Pain Induced by Tooth Movement. Biomed Res Int. 2021;2021:4229491Read more>>
- An Wang. et al. Yiqi Jiedu herbal decoction attenuates the 2?Gy 60Co ray induced spleen injury by inhibiting apoptosis and modulating the immune balance. J Ethnopharmacol. 2022 Mar;286:114925Read more>>
- Yan Zhang. et al. Ganoderic Acid A To Alleviate Neuroinflammation of Alzheimers Disease in Mice by Regulating the Imbalance of the Th17/Tregs Axis. J Agr Food Chem. 2021;69(47):14204C14214Read more>>
- Minghui Li. et al. Rho Kinase regulates neutrophil NET formation that is involved in UVB-induced skin inflammation. Theranostics. 2022; 12(5): 21332149Read more>>
- Tin-Yun Ho. et al. Rosmarinic acid ameliorated psoriatic skin inflammation in mice through the novel inhibition on interleukin-17A/interleukin-17A receptor interaction. FOOD FUNCT. 2022 MayRead more>>
- Jia, Yu. et al. The treatment of Qibai Pingfei Capsule on chronic obstructive pulmonary disease may be mediated by Th17/Treg balance and gut-lung axis microbiota. J TRANSL MED. 2022 Dec;20(1):1-21Read more>>
- Xiaoyu Guo. et al. Effects of Boric Acid Gel on Vaginal Candida albicans Infections and the Local Immune System in Mice. FRONT IMMUNOL. 2022; 13: 950215Read more>>
- Feng Huang. et al. NMR-based metabolomic analysis for the effects of moxibustion on imiquimod-induced psoriatic mice. J ETHNOPHARMACOL. 2023 Jan;300:115626Read more>>
- Emin Kaymak. et al. Thymoquinone alleviates doxorubicin induced acute kidney injury by decreasing endoplasmic reticulum stress, inflammation and apoptosis. BIOTECH HISTOCHEM. 2022 Aug 22Read more>>
- Sun, Xinxin. et al. 0.1% Nano-silver mediates PD-1/PD-L1 pathway and alleviates chronic apical periodontitis in rats. ODONTOLOGY. 2022 Sep;:1-11Read more>>
- Prema Robinson. et al. Genetic and Small-Molecule Modulation of Stat3 in a Mouse Model of Crohn’s Disease. J CLIN MED. 2022 Jan;11(23):702Read more>>
- Yuan, Xulei. et al. Systemic antibiotics increase microbiota pathogenicity and oral bone loss. INT J ORAL SCI. 2023 Jan;15(1):1-14Read more>>
- Qingqing Liu. et al. A Synbiotic Ameliorates Con A-Induced Autoimmune Hepatitis in Mice Through Modulation of Gut Microbiota And Immune Imbalance. MOL NUTR FOOD RES. 2023 Jan;:2200428Read more>>
- Yongbo Kang. et al. A Novel Synbiotic Alleviates Autoimmune Hepatitis by Modulating the Gut Microbiota-Liver Axis and Inhibiting the Hepatic TLR4/NF-B/NLRP3 Signaling Pathway. MSYSTEMS. 2023 Feb 16Read more>>
- Mingwei Tong. et al. The Trichinella spiralis-derived antigens alleviate HFD-induced obesity and inflammation in mice. INT IMMUNOPHARMACOL. 2023 Apr;117:109924Read more>>
- Huangguan Qin. et al. Toddalia asiatica extract attenuates adjuvant-induced arthritis by modulating colon Th17/Treg balance and colony homeostasis. J ETHNOPHARMACOL. 2023 Apr;:116542Read more>>
- Yang LIU. et al. Platycodon grandiflorus polysaccharide regulates colonic immunity through mesenteric lymphatic circulation to attenuate ulcerative colitis. CHIN J NAT MEDICINES. 2023 Apr;21:263Read more>>
- Prema Robinson. et al. Therapeutic Potential of a Small-Molecule STAT3 Inhibitor in a Mouse Model of Colitis. CANCERS. 2023 Jan;15(11):2977Read more>>
- Shuang Hu. et al. Study on therapeutic mechanism of total salvianolic acids against myocardial ischemia-reperfusion injury based on network pharmacology, molecular docking, and experimental study. J ETHNOPHARMACOL. 2024 May;326:117902Read more>>
- Hao Zhou. et al. Microenvironment-responsive metal-phenolic network release platform with ROS scavenging, anti-pyroptosis, and ECM regeneration for intervertebral disc degeneration. BIOACT MATER. 2024 Jul;37:51Read more>>
VALIDATION IMAGES
Formalin-fixed and paraffin embedded rat stomach tissue labeled with Anti-IL-17/IL-17A Polyclonal Antibody, Unconjugated(bs-1183R) at 1:600 followed by conjugation to the secondary antibody and DAB staining
Formalin-fixed and paraffin embedded rat tongue tissue labeled with Anti-IL-17/IL-17A Polyclonal Antibody, Unconjugated(bs-1183R) at 1:600 followed by conjugation to the secondary antibody and DAB staining
Lane 1: Rat Lymph node tissue lysates; Lane 2: Mouse Lymph node tissue lysates; Lane 3: Rat Thymus tissue lysates probed with IL17A Polyclonal Antibody, Unconjugated (bs-1183R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.