bs-11740R-Cy7 [Conjugated Primary Antibody]
EBF2 Polyclonal Antibody, Cy7 Conjugated
www.biossusa.com
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Host: Rabbit

Target Protein: EBF2

Immunogen Range: 331-400/575


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 64641

Swiss Prot: Q9HAK2

Source: KLH conjugated synthetic peptide derived from human EBF2

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Early B-cell factor 2 is a 575 amino acid protein belonging to the COE family of proteins, whose members are all helix-loop-helix transcription factors. EBF2 is a transcription factor which, in synergy with the Wnt-responsive LEF1/CTNNB1 pathway, activates the decoy receptor for RANKL, OPG, in osteoblasts. OPG, in turn, regulates osteoclast differentiation. Lack of EBF2 has been found to cause a small defect in the terminal differentiation of osteoblasts, along with reduced bone mass and an increase in osteoclasts. Localized to the nucleus, EBF2 forms a homodimer or a heterodimer with a related family member.

Conjugation: Cy7

Excitation/ Emission: 743nm/767nm

Size: 100ul

Concentration: 1ug/ul

Applications: IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 63


Predicted Cross Reactive Species: Human
Mouse
Rat
Dog
Cow
Sheep
Pig
Horse
Rabbit

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Hui J. Wang. et al. Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation. Nat Commun. 2020 Oct;11(1):1-2Read more>>
  • Chen, Yan-Ting. et al. Imprinted lncRNA Dio3os preprograms intergenerational brown fat development and obesity resistance. Nat Commun. 2021 Nov;12(1):1-18Read more>>
  • Andrea Estefana Portales. et al. CDK4/6 are necessary for UCP1-mediated thermogenesis of white adipose tissue. LIFE SCI. 2023 Jun;322:121652Read more>>