DATASHEET
Host:
Rabbit
Target Protein:
CCR4
Immunogen Range:
201-300/360
Clonality:
Polyclonal
Isotype:
IgG
Entrez Gene:
1233
Swiss Prot:
P51679
Source:
KLH conjugated synthetic peptide derived from human CCR-4
Purification:
Purified by Protein A.
Storage Buffer:
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage:
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Background:
High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
PRODUCT SPECIFIC PUBLICATIONS
- Ge, L. P., et al. "Integration of nondegradable polystyrene and degradable gelatin in a core–sheath nanofibrous patch for pelvic reconstruction." International Journal of Nanomedicine 2015:10 3193–3201Read more>>
- Nicolas Pelisch. et al. CCL3 contributes to secondary damage after spinal cord injury. J Neuroinflamm. 2020 Dec;17(1):1-16Read more>>
- Han, Dongxu. et al. Subacute cadmium exposure modulates Th1 polarization to trigger ER stress-induced porcine hepatocyte apoptosis via regulation of miR-369-TNF axis. 2021 Oct 14Read more>>
- Lin Liu. et al. Potential Applications of Dual Haptoglobin Expression in the Reclassification and Treatment of Hepatocellular Carcinoma. TRANSL RES. 2024 MayRead more>>
VALIDATION IMAGES
Formalin-fixed and paraffin embedded rat exfoliated cells tissue labeled with Anti-CCR4 Polyclonal Antibody, Unconjugated (bs-1168R) at 1:200 followed by conjugation to the secondary antibody and DAB staining
Formalin-fixed and paraffin embedded rat cells labeled with Anti-CCR4/CD194 Polyclonal Antibody, Unconjugated (bs-1168R) followed by conjugation to the secondary antibody and DAB staining
Formalin-fixed and paraffin embedded human hepatitides tissue labeled with Anti-CCR4 Polyclonal Antibody, Unconjugated (bs-1168R) at 1:200 followed by conjugation to the secondary antibody and DAB staining