bs-11514R [Primary Antibody]
CCKAR Polyclonal Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: CCKAR

Immunogen Range: 161-200/428


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 886

Swiss Prot: P32238

Source: KLH conjugated synthetic peptide derived from human CCKAR

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Background:

Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
ELISA(1:500-1000)
FCM(1:20-100)
IHC-P(1:200-400)
IHC-F(1:100-500)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)
ICC(1:100-500)

Predicted Molecular Weight: 48


Cross Reactive Species: Human
Mouse
Rat
Chicken

Predicted Cross Reactive Species: Dog
Cow
Sheep
Pig
Horse

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • El-Kassas, S., et al. "Expression and Regulation of Cholecystokinin Receptor in the Chicken’s Immune Organs and Cells." J Clin Cell Immunol7.471 (2016): 2.Read more>>
  • El-Kassas et al. Expression and Regulation of Cholecystokinin Receptor in the Chicken's Immune Organs and Cells. (2016) J.Clin.Cell.Immunol. 7 Read more>>
  • Lu-Lu Duan. et al. Spinal CCK contributes to somatic hyperalgesia induced by orofacial inflammation combined with stress in adult female rats. Eur J Pharmacol. 2021 Dec;913:174619Read more>>
  • Kristine Elisabeth Eberhard. et al. Neurotransmitter and Neurotransmitter Receptor Expression in the Saccule of the Human Vestibular System. Prog Neurobiol. 2022 Jan;:102238Read more>>
  • Ting Xiang. et al. Spinal CCK1 receptors contribute to somatic pain hypersensitivity induced by malocclusion via a reciprocal neuron-glial signaling cascade. J PAIN. 2022 JuRead more>>
  • Jia-Heng Li. et al. Chronic stress induces wide-spread hyperalgesia: The involvement of spinal CCK1 receptors. NEUROPHARMACOLOGY. 2024 Nov;258:110067Read more>>
VALIDATION IMAGES

Lane 1: Mouse pancreas lysates probed with Anti CCKAR Polyclonal Antibody, Unconjugated (bs-11514R) at 1:300 overnight at 4˚C. Followed by a conjugated secondary antibody at 1:5000 for 90 min at 37˚C.