bs-1124R [Primary Antibody]
5-HTR1A Polyclonal Antibody
www.biossusa.com
[email protected]
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+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: 5-HTR1A

Immunogen Range: 301-400/422


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 24473

Swiss Prot: P19327

Source: KLH conjugated synthetic peptide derived from rat 5-HTR1A

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Background:

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
ELISA(1:500-1000)
IHC-F(1:100-500)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 46


Cross Reactive Species: Human
Mouse
Rat

Predicted Cross Reactive Species: Dog
Horse
Rabbit

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Yeh, C-B., et al. "Calcitonin alleviates hyperalgesia in osteoporotic rats by modulating serotonin transporter activity." Osteoporosis International (2016): 1-10.Read more>>
  • Zhou, Q. G., et al. "Reactivation of Tert in the medial prefrontal cortex and hippocampus rescues aggression and depression of Tert−/− mice."Translational Psychiatry 6.6 (2016): e836.Read more>>
  • Lan Yao. et al. Armillaria mellea fermentation liquor ameliorates p-chlorophenylalanine-induced insomnia associated with the modulation of serotonergic system and gut microbiota in rats. 2022 Jan 05Read more>>
  • Taotao Li. et al. Rosemary (Rosmarinus officinalis L.) hydrosol based on serotonergic synapse for insomnia. J ETHNOPHARMACOL. 2023 Jul;:116984Read more>>
VALIDATION IMAGES

Lane 1: Mouse Brain Lysates; Lane 2: Mouse Cerebellum Lysate; Lane 3: Mouse Lymph Lysates; Lane 4: Rat Brain Lysates; Lane 5: Rat Cerebellum Lysates. Probed with 5HT1A Receptor polyclonal Antibody, unconjugated (bs-1124R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.